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A unique Oct4 interface is crucial for reprogramming to pluripotency.
Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR. Esch D, et al. Among authors: scholer hr. Nat Cell Biol. 2013 Mar;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3. Nat Cell Biol. 2013. PMID: 23376973
Changing POU dimerization preferences converts Oct6 into a pluripotency inducer.
Jerabek S, Ng CK, Wu G, Arauzo-Bravo MJ, Kim KP, Esch D, Malik V, Chen Y, Velychko S, MacCarthy CM, Yang X, Cojocaru V, Schöler HR, Jauch R. Jerabek S, et al. Among authors: scholer hr. EMBO Rep. 2017 Feb;18(2):319-333. doi: 10.15252/embr.201642958. Epub 2016 Dec 22. EMBO Rep. 2017. PMID: 28007765 Free PMC article.
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2.
Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Malik V, et al. Among authors: scholer hr. Nat Commun. 2019 Aug 2;10(1):3477. doi: 10.1038/s41467-019-11054-7. Nat Commun. 2019. PMID: 31375664 Free PMC article.
Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding.
Huertas J, MacCarthy CM, Schöler HR, Cojocaru V. Huertas J, et al. Among authors: scholer hr. Biophys J. 2020 May 5;118(9):2280-2296. doi: 10.1016/j.bpj.2019.12.038. Epub 2020 Jan 16. Biophys J. 2020. PMID: 32027821 Free PMC article.
321 results