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Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington's disease.
Pepe G, Capocci L, Marracino F, Realini N, Lenzi P, Martinello K, Bovier TF, Bichell TJ, Scarselli P, Di Cicco C, Bowman AB, Digilio FA, Fucile S, Fornai F, Armirotti A, Parlato R, Di Pardo A, Maglione V. Pepe G, et al. Among authors: scarselli p. Mol Ther. 2023 Jan 4;31(1):282-299. doi: 10.1016/j.ymthe.2022.09.004. Epub 2022 Sep 16. Mol Ther. 2023. PMID: 36116006 Free PMC article.
Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models.
Pepe G, Cotugno M, Marracino F, Capocci L, Pizzati L, Forte M, Stanzione R, Scarselli P, Di Pardo A, Sciarretta S, Volpe M, Rubattu S, Maglione V. Pepe G, et al. Among authors: scarselli p. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Jan;1869(1):159411. doi: 10.1016/j.bbalip.2023.159411. Epub 2023 Nov 9. Biochim Biophys Acta Mol Cell Biol Lipids. 2024. PMID: 37949293
Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.
Notartomaso S, Zappulla C, Biagioni F, Cannella M, Bucci D, Mascio G, Scarselli P, Fazio F, Weisz F, Lionetto L, Simmaco M, Gradini R, Battaglia G, Signore M, Puliti A, Nicoletti F. Notartomaso S, et al. Among authors: scarselli p. Mol Brain. 2013 Nov 19;6:48. doi: 10.1186/1756-6606-6-48. Mol Brain. 2013. PMID: 24252411 Free PMC article.
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F, Goudet C. Fazio F, et al. Among authors: scarselli p. Mol Pharmacol. 2012 May;81(5):643-56. doi: 10.1124/mol.111.074765. Epub 2012 Feb 6. Mol Pharmacol. 2012. PMID: 22311707
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, Imbriglio T, Gradini R, Battaglia G, Bruno V, Nicoletti F. Notartomaso S, et al. Among authors: scarselli p. Mol Pain. 2017 Jan;13:1744806917697009. doi: 10.1177/1744806917697009. Mol Pain. 2017. PMID: 28326943 Free PMC article.
N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy.
Notartomaso S, Scarselli P, Mascio G, Liberatore F, Mazzon E, Mammana S, Gugliandolo A, Cruccu G, Bruno V, Nicoletti F, Battaglia G. Notartomaso S, et al. Among authors: scarselli p. Mol Pain. 2020 Jan-Dec;16:1744806920904292. doi: 10.1177/1744806920904292. Mol Pain. 2020. PMID: 32009537 Free PMC article.
Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.
Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F. Fazio F, et al. Among authors: scarselli p. Neuropharmacology. 2014 Jun;81:237-43. doi: 10.1016/j.neuropharm.2014.02.011. Epub 2014 Feb 21. Neuropharmacology. 2014. PMID: 24565643
Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain.
Notartomaso S, Boccella S, Antenucci N, Ricciardi F, Fazio F, Liberatore F, Scarselli P, Scioli M, Mascio G, Bruno V, Battaglia G, Nicoletti F, Maione S, Luongo L. Notartomaso S, et al. Among authors: scarselli p. Front Mol Neurosci. 2022 Jun 2;15:892870. doi: 10.3389/fnmol.2022.892870. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35721314 Free PMC article.
18 results