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Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.
Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. Moreno-Sanz G, et al. Among authors: scarpelli r. J Med Chem. 2013 Jul 25;56(14):5917-30. doi: 10.1021/jm4007017. Epub 2013 Jul 3. J Med Chem. 2013. PMID: 23822179 Free PMC article.
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.
Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. Sasso O, et al. Among authors: scarpelli r. FASEB J. 2015 Jun;29(6):2616-27. doi: 10.1096/fj.15-270637. Epub 2015 Mar 10. FASEB J. 2015. PMID: 25757568 Free PMC article.
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.
Caputo S, Di Martino S, Cilibrasi V, Tardia P, Mazzonna M, Russo D, Penna I, Summa M, Bertozzi SM, Realini N, Margaroli N, Migliore M, Ottonello G, Liu M, Lansbury P, Armirotti A, Bertorelli R, Ray SS, Skerlj R, Scarpelli R. Caputo S, et al. Among authors: scarpelli r. J Med Chem. 2020 Dec 24;63(24):15821-15851. doi: 10.1021/acs.jmedchem.0c01561. Epub 2020 Dec 8. J Med Chem. 2020. PMID: 33290061 Free PMC article.
A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase.
Bertolacci L, Romeo E, Veronesi M, Magotti P, Albani C, Dionisi M, Lambruschini C, Scarpelli R, Cavalli A, De Vivo M, Piomelli D, Garau G. Bertolacci L, et al. Among authors: scarpelli r. J Am Chem Soc. 2013 Jan 9;135(1):22-5. doi: 10.1021/ja308733u. Epub 2012 Dec 21. J Am Chem Soc. 2013. PMID: 23240907 Free PMC article.
Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.
Moreno-Sanz G, Barrera B, Armirotti A, Bertozzi SM, Scarpelli R, Bandiera T, Prieto JG, Duranti A, Tarzia G, Merino G, Piomelli D. Moreno-Sanz G, et al. Among authors: scarpelli r. Pharmacol Res. 2014 Sep;87:87-93. doi: 10.1016/j.phrs.2014.06.004. Epub 2014 Jun 30. Pharmacol Res. 2014. PMID: 24993496 Free PMC article.
52 results