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Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication.
Cell Host Microbe. 2023 Aug 9;31(8):1317-1330.e10. doi: 10.1016/j.chom.2023.06.013. Epub 2023 Jul 20.
Cell Host Microbe. 2023.
PMID: 37478852
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Afsar M, Liu G, Jia L, Ruben EA, Nayak D, Sayyad Z, Bury PDS, Cano KE, Nayak A, Zhao XR, Shukla A, Sung P, Wasmuth EV, Gack MU, Olsen SK.
Afsar M, et al. Among authors: sayyad z.
Nat Commun. 2023 Aug 8;14(1):4786. doi: 10.1038/s41467-023-39780-z.
Nat Commun. 2023.
PMID: 37553340
Free PMC article.
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A glaucoma-associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α.
Sayyad Z, Kaveti S, Bhattacharjee D, Vedagiri D, Jain N, Swarup G.
Sayyad Z, et al.
FEBS J. 2023 Jun;290(12):3110-3127. doi: 10.1111/febs.16739. Epub 2023 Feb 7.
FEBS J. 2023.
PMID: 36705529
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Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.
Sayyad Z, Vishwakarma S, Dave TV, Naik MN, Radha V, Kaur I, Swarup G.
Sayyad Z, et al.
Neurochem Int. 2021 Sep;148:105075. doi: 10.1016/j.neuint.2021.105075. Epub 2021 May 20.
Neurochem Int. 2021.
PMID: 34023378
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A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.
Medchalmi S, Tare P, Sayyad Z, Swarup G.
Medchalmi S, et al. Among authors: sayyad z.
FEBS J. 2021 Aug;288(15):4576-4595. doi: 10.1111/febs.15752. Epub 2021 Feb 19.
FEBS J. 2021.
PMID: 33548116
Free article.
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Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.
Swarup G, Sayyad Z.
Swarup G, et al. Among authors: sayyad z.
Front Immunol. 2018 Jun 6;9:1287. doi: 10.3389/fimmu.2018.01287. eCollection 2018.
Front Immunol. 2018.
PMID: 29951055
Free PMC article.
Review.
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661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
Sayyad Z, Sirohi K, Radha V, Swarup G.
Sayyad Z, et al.
Sci Rep. 2017 Dec 4;7(1):16855. doi: 10.1038/s41598-017-17241-0.
Sci Rep. 2017.
PMID: 29203899
Free PMC article.
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Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates.
Kolla VK, Prasad R, Sayyad Z, Atul, Shah AY, Allanki AD, Navale R, Singhal N, Tanneru N, Sudhakar R, Venkatesan V, Deshmukh MV, Sijwali PS.
Kolla VK, et al. Among authors: sayyad z.
Mol Biochem Parasitol. 2015 Aug;202(2):11-22. doi: 10.1016/j.molbiopara.2015.09.005. Epub 2015 Oct 9.
Mol Biochem Parasitol. 2015.
PMID: 26439304
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