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Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.
Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Fay EJ, Castro LK, Beierschmitt C, Yap C, Turcotte EA, Delgado-Rodriguez SE, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD. Tsu BV, et al. Among authors: savan r. PLoS Biol. 2023 Jun 8;21(6):e3002144. doi: 10.1371/journal.pbio.3002144. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37289745 Free PMC article.
Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.
Harioudh MK, Perez J, Chong Z, Nair S, So L, McCormick KD, Ghosh A, Shao L, Srivastava R, Soveg F, Ebert TS, Atianand MK, Hornung V, Savan R, Diamond MS, Sarkar SN. Harioudh MK, et al. Among authors: savan r. Immunity. 2024 Mar 12;57(3):446-461.e7. doi: 10.1016/j.immuni.2024.02.002. Epub 2024 Feb 28. Immunity. 2024. PMID: 38423012
CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.
Gokhale NS, Somfleth K, Thompson MG, Sam RK, Marciniak DM, Chu LH, Park M, Dvorkin S, Oberst A, Horner SM, Ong SE, Gale M Jr, Savan R. Gokhale NS, et al. Among authors: savan r. bioRxiv [Preprint]. 2023 Sep 25:2023.09.25.559083. doi: 10.1101/2023.09.25.559083. bioRxiv. 2023. PMID: 37808873 Free PMC article. Preprint.
Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.
Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Castro LK, Beierschmitt CM, Turcotte EA, Fay EJ, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD. Tsu BV, et al. Among authors: savan r. bioRxiv [Preprint]. 2022 Sep 22:2022.09.21.508960. doi: 10.1101/2022.09.21.508960. bioRxiv. 2022. PMID: 36172130 Free PMC article. Updated. Preprint.
ADAR1 mutation causes ZBP1-dependent immunopathology.
Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A. Hubbard NW, et al. Among authors: savan r. Nature. 2022 Jul;607(7920):769-775. doi: 10.1038/s41586-022-04896-7. Epub 2022 Jul 20. Nature. 2022. PMID: 35859177 Free PMC article.
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease.
Henden AS, Koyama M, Robb RJ, Forero A, Kuns RD, Chang K, Ensbey KS, Varelias A, Kazakoff SH, Waddell N, Clouston AD, Giri R, Begun J, Blazar BR, Degli-Esposti MA, Kotenko SV, Lane SW, Bowerman KL, Savan R, Hugenholtz P, Gartlan KH, Hill GR. Henden AS, et al. Among authors: savan r. Blood. 2021 Aug 26;138(8):722-737. doi: 10.1182/blood.2020006375. Blood. 2021. PMID: 34436524 Free PMC article.
79 results