Sasaguri H - Search Results

1

A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.

Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VM, He Z. Zhao X, et al. Among authors: sasaguri h. Sci Transl Med. 2023 Sep 13;15(713):eabo6889. doi: 10.1126/scitranslmed.abo6889. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703352 Free PMC article.

2

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.

Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. Saito T, et al. Among authors: sasaguri h. J Biol Chem. 2019 Aug 23;294(34):12754-12765. doi: 10.1074/jbc.RA119.009487. Epub 2019 Jul 4. J Biol Chem. 2019. PMID: 31273083 Free PMC article.

3

APP mouse models for Alzheimer's disease preclinical studies.

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. Sasaguri H, et al. EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1. EMBO J. 2017. PMID: 28768718 Free PMC article. Review.

4

Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters.

Sutoko S, Masuda A, Kandori A, Sasaguri H, Saito T, Saido TC, Funane T. Sutoko S, et al. Among authors: sasaguri h. iScience. 2021 Feb 16;24(3):102198. doi: 10.1016/j.isci.2021.102198. eCollection 2021 Mar 19. iScience. 2021. PMID: 33733064 Free PMC article.

5

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App^{NL-G-F/NL-G-F} mice.

Niikura R, Miyazaki T, Takase K, Sasaguri H, Saito T, Saido TC, Goto T. Niikura R, et al. Among authors: sasaguri h. Mol Brain. 2022 Apr 7;15(1):32. doi: 10.1186/s13041-022-00910-1. Mol Brain. 2022. PMID: 35387663 Free PMC article.

6

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

Sato K, Watamura N, Fujioka R, Mihira N, Sekiguchi M, Nagata K, Ohshima T, Saito T, Saido TC, Sasaguri H. Sato K, et al. Among authors: sasaguri h. J Biol Chem. 2021 Sep;297(3):101004. doi: 10.1016/j.jbc.2021.101004. Epub 2021 Jul 27. J Biol Chem. 2021. PMID: 34329683 Free PMC article.

7

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Watamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Mihira N, Fujioka R, Nagata K, Hashimoto S, Saito T, Ohshima T, Saido TC, Sasaguri H. Watamura N, et al. Among authors: sasaguri h. Sci Adv. 2022 Jun 10;8(23):eabm6155. doi: 10.1126/sciadv.abm6155. Epub 2022 Jun 8. Sci Adv. 2022. PMID: 35675411 Free PMC article.

8

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K_ATP channel pathway.

Watamura N, Kakiya N, Nilsson P, Tsubuki S, Kamano N, Takahashi M, Hashimoto S, Sasaguri H, Saito T, Saido TC. Watamura N, et al. Among authors: sasaguri h. Mol Psychiatry. 2022 Mar;27(3):1816-1828. doi: 10.1038/s41380-021-01368-8. Epub 2021 Nov 4. Mol Psychiatry. 2022. PMID: 34737456 Free PMC article.

9

Recent Advances in the Modeling of Alzheimer's Disease.

Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nilsson P, Winblad B, Saito T, Iwata N, Saido TC. Sasaguri H, et al. Front Neurosci. 2022 Mar 31;16:807473. doi: 10.3389/fnins.2022.807473. eCollection 2022. Front Neurosci. 2022. PMID: 35431779 Free PMC article. Review.

10

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Sasaguri H, et al. Nat Commun. 2018 Jul 24;9(1):2892. doi: 10.1038/s41467-018-05262-w. Nat Commun. 2018. PMID: 30042426 Free PMC article.

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