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Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM.
Le T, Jeanne Dit Fouque K, Santos-Fernandez M, Navo CD, Jiménez-Osés G, Sarksian R, Fernandez-Lima FA, van der Donk WA. Le T, et al. Among authors: sarksian r. J Am Chem Soc. 2021 Nov 10;143(44):18733-18743. doi: 10.1021/jacs.1c09370. Epub 2021 Nov 1. J Am Chem Soc. 2021. PMID: 34724611 Free PMC article.
Divergent Evolution of Lanthipeptide Stereochemistry.
Sarksian R, van der Donk WA. Sarksian R, et al. ACS Chem Biol. 2022 Sep 16;17(9):2551-2558. doi: 10.1021/acschembio.2c00492. Epub 2022 Aug 24. ACS Chem Biol. 2022. PMID: 36001880 Free PMC article.
Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical.
Lundahl MN, Sarksian R, Yang H, Jodts RJ, Pagnier A, Smith DF, Mosquera MA, van der Donk WA, Hoffman BM, Broderick WE, Broderick JB. Lundahl MN, et al. Among authors: sarksian r. J Am Chem Soc. 2022 Mar 23;144(11):5087-5098. doi: 10.1021/jacs.1c13706. Epub 2022 Mar 8. J Am Chem Soc. 2022. PMID: 35258967 Free PMC article.
A scalable platform to discover antimicrobials of ribosomal origin.
Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, Precord TW, van der Donk WA, Mitchell DA, Zhao H. Ayikpoe RS, et al. Among authors: sarksian r. Nat Commun. 2022 Oct 17;13(1):6135. doi: 10.1038/s41467-022-33890-w. Nat Commun. 2022. PMID: 36253467 Free PMC article.
Improved production of class I lanthipeptides in Escherichia coli.
Lee H, Wu C, Desormeaux EK, Sarksian R, van der Donk WA. Lee H, et al. Among authors: sarksian r. Chem Sci. 2023 Feb 13;14(10):2537-2546. doi: 10.1039/d2sc06597e. eCollection 2023 Mar 8. Chem Sci. 2023. PMID: 36908960 Free PMC article.