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The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.
Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S. Toboz P, et al. Among authors: santos mm. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2121251119. doi: 10.1073/pnas.2121251119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994670 Free PMC article.
Anemia upregulates lipocalin 2 in the liver and serum.
Jiang W, Constante M, Santos MM. Jiang W, et al. Among authors: santos mm. Blood Cells Mol Dis. 2008 Sep-Oct;41(2):169-74. doi: 10.1016/j.bcmd.2008.04.006. Epub 2008 Jun 2. Blood Cells Mol Dis. 2008. PMID: 18519167 Free PMC article.
Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.
Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K. Kent P, et al. Among authors: santos mm. J Mol Med (Berl). 2015 May;93(5):489-98. doi: 10.1007/s00109-015-1253-7. Epub 2015 Jan 23. J Mol Med (Berl). 2015. PMID: 25609138
651 results