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Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice.
Duarte TL, Lopes M, Oliveira M, Santos AG, Vasco C, Reis JP, Antunes AR, Gonçalves A, Chacim S, Oliveira C, Porto B, Teles MJ, Moreira AC, Silva AMN, Schwessinger R, Drakesmith H, Henrique R, Porto G, Duarte D. Duarte TL, et al. Among authors: santos ag. Leukemia. 2024 Jan;38(1):96-108. doi: 10.1038/s41375-023-02067-9. Epub 2023 Oct 19. Leukemia. 2024. PMID: 37857886
Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.
Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H. Lim PJ, et al. Among authors: santos goncalves a, santos ag. Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13. Nat Metab. 2019. PMID: 31276102 Free PMC article.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. Pasricha SR, et al. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. Nat Commun. 2017. PMID: 28864822 Free PMC article.
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.
Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Elife. 2016 Nov 29;5:e19804. doi: 10.7554/eLife.19804. Elife. 2016. PMID: 27897970 Free PMC article.
Prone positioning in awake patients without ventilatory support does not alter major clinical outcomes in severe COVID-19: results from a retrospective observational cohort study, systematic review and meta-analysis.
Freire RS, Barros CMSS, Valente J, Goulart CDL, Santos AGR, Fonseca FH, Saenz ST, Dias AS, Rodrigues MGA, Silva BM, Fernandes E, Cubas-Vega N, Sampaio V, Simão M, Baía-da-Silva D, Severin R, Arêas GPT, Gonçalves RL, Mendes RG, Martinez-Espinosa FE, Val F. Freire RS, et al. Among authors: santos agr. Expert Rev Respir Med. 2024 May 9:1-8. doi: 10.1080/17476348.2024.2350587. Online ahead of print. Expert Rev Respir Med. 2024. PMID: 38712558
Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial.
Messina NL, Germano S, McElroy R, Bonnici R, Grubor-Bauk B, Lynn DJ, McDonald E, Nicholson S, Perrett KP, Pittet LF, Rudraraju R, Stevens NE, Subbarao K, Curtis N; BRACE trial. Messina NL, et al. EBioMedicine. 2024 Apr 23;103:105100. doi: 10.1016/j.ebiom.2024.105100. Online ahead of print. EBioMedicine. 2024. PMID: 38663355 Free PMC article.
159 results