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Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.
Varkaris A, Fece de la Cruz F, Martin EE, Norden BL, Chevalier N, Kehlmann AM, Leshchiner I, Barnes H, Ehnstrom S, Stavridi AM, Yuan X, Kim JS, Ellis H, Papatheodoridi A, Gunaydin H, Danysh BP, Parida L, Sanidas I, Ji Y, Lau K, Wulf GM, Bardia A, Spring LM, Isakoff SJ, Lennerz JK, Del Vecchio K, Pierce L, Pazolli E, Getz G, Corcoran RB, Juric D. Varkaris A, et al. Among authors: sanidas i. Cancer Discov. 2024 Feb 8;14(2):227-239. doi: 10.1158/2159-8290.CD-23-0704. Cancer Discov. 2024. PMID: 37916958 Free PMC article.
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer.
Costa C, Wang Y, Ly A, Hosono Y, Murchie E, Walmsley CS, Huynh T, Healy C, Peterson R, Yanase S, Jakubik CT, Henderson LE, Damon LJ, Timonina D, Sanidas I, Pinto CJ, Mino-Kenudson M, Stone JR, Dyson NJ, Ellisen LW, Bardia A, Ebi H, Benes CH, Engelman JA, Juric D. Costa C, et al. Among authors: sanidas i. Cancer Discov. 2020 Jan;10(1):72-85. doi: 10.1158/2159-8290.CD-18-0830. Epub 2019 Oct 8. Cancer Discov. 2020. PMID: 31594766
Clinical Outcomes With Abemaciclib After Prior CDK4/6 Inhibitor Progression in Breast Cancer: A Multicenter Experience.
Wander SA, Han HS, Zangardi ML, Niemierko A, Mariotti V, Kim LSL, Xi J, Pandey A, Dunne S, Nasrazadani A, Kambadakone A, Stein C, Lloyd MR, Yuen M, Spring LM, Juric D, Kuter I, Sanidas I, Moy B, Mulvey T, Vidula N, Dyson NJ, Ellisen LW, Isakoff S, Wagle N, Brufsky A, Kalinsky K, Ma CX, O'Shaughnessy J, Bardia A. Wander SA, et al. Among authors: sanidas i. J Natl Compr Canc Netw. 2021 Mar 24:1-8. doi: 10.6004/jnccn.2020.7662. Online ahead of print. J Natl Compr Canc Netw. 2021. PMID: 33761455
Active RB causes visible changes in nuclear organization.
Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, Lawrence MS, Zou L, Nieman LT, Sanidas I, Dyson NJ. Krishnan B, et al. Among authors: sanidas i. J Cell Biol. 2022 Mar 7;221(3):e202102144. doi: 10.1083/jcb.202102144. Epub 2022 Jan 12. J Cell Biol. 2022. PMID: 35019938 Free PMC article.
Seeing is believing: the impact of RB on nuclear organization.
Krishnan B, Sanidas I, Dyson NJ. Krishnan B, et al. Among authors: sanidas i. Cell Cycle. 2023 Jun;22(11):1357-1366. doi: 10.1080/15384101.2023.2206352. Epub 2023 May 3. Cell Cycle. 2023. PMID: 37139582 Free PMC article.
A Code of Mono-phosphorylation Modulates the Function of RB.
Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ. Sanidas I, et al. Mol Cell. 2019 Mar 7;73(5):985-1000.e6. doi: 10.1016/j.molcel.2019.01.004. Epub 2019 Jan 30. Mol Cell. 2019. PMID: 30711375 Free PMC article.
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.
Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Nicolay BN, et al. Among authors: sanidas i. Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27. Genes Dev. 2015. PMID: 26314710 Free PMC article.
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