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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW. Vervoort SJ, et al. Among authors: sandow jj. Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17. Cell. 2021. PMID: 34004147 Free PMC article.
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.
Fan Z, Devlin JR, Hogg SJ, Doyle MA, Harrison PF, Todorovski I, Cluse LA, Knight DA, Sandow JJ, Gregory G, Fox A, Beilharz TH, Kwiatkowski N, Scott NE, Vidakovic AT, Kelly GP, Svejstrup JQ, Geyer M, Gray NS, Vervoort SJ, Johnstone RW. Fan Z, et al. Among authors: sandow jj. Sci Adv. 2020 Apr 29;6(18):eaaz5041. doi: 10.1126/sciadv.aaz5041. Print 2020 May. Sci Adv. 2020. PMID: 32917631 Free PMC article.
CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory.
Lelliott EJ, Kong IY, Zethoven M, Ramsbottom KM, Martelotto LG, Meyran D, Zhu JJ, Costacurta M, Kirby L, Sandow JJ, Lim L, Dominguez PM, Todorovski I, Haynes NM, Beavis PA, Neeson PJ, Hawkins ED, McArthur GA, Parish IA, Johnstone RW, Oliaro J, Sheppard KE, Kearney CJ, Vervoort SJ. Lelliott EJ, et al. Among authors: sandow jj. Cancer Discov. 2021 Oct;11(10):2582-2601. doi: 10.1158/2159-8290.CD-20-1554. Epub 2021 May 14. Cancer Discov. 2021. PMID: 33990344
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.
Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, Fan Z, Jabbari JS, Martin BP, Fareh M, Kelly MJ, Dupéré-Richer D, Sandow JJ, Feran B, Knight D, Khong T, Spencer A, Harrison SJ, Gregory G, Wickramasinghe VO, Webb AI, Taberlay PC, Bromberg KD, Lai A, Papenfuss AT, Smyth GK, Allan RS, Licht JD, Landau DA, Abdel-Wahab O, Shortt J, Vervoort SJ, Johnstone RW. Hogg SJ, et al. Among authors: sandow jj. Mol Cell. 2021 May 20;81(10):2183-2200.e13. doi: 10.1016/j.molcel.2021.04.015. Mol Cell. 2021. PMID: 34019788 Free PMC article.
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.
Lim Y, De Bellis D, Sandow JJ, Capalbo L, D'Avino PP, Murphy JM, Webb AI, Dorstyn L, Kumar S. Lim Y, et al. Among authors: sandow jj. Cell Death Differ. 2021 Jan;28(1):349-366. doi: 10.1038/s41418-020-00604-y. Epub 2020 Aug 18. Cell Death Differ. 2021. PMID: 32811973 Free PMC article.
The regulation of necroptosis by post-translational modifications.
Meng Y, Sandow JJ, Czabotar PE, Murphy JM. Meng Y, et al. Among authors: sandow jj. Cell Death Differ. 2021 Mar;28(3):861-883. doi: 10.1038/s41418-020-00722-7. Epub 2021 Jan 18. Cell Death Differ. 2021. PMID: 33462412 Free PMC article. Review.
Hoxb8 regulates expression of microRNAs to control cell death and differentiation.
Salmanidis M, Brumatti G, Narayan N, Green BD, van den Bergen JA, Sandow JJ, Bert AG, Silke N, Sladic R, Puthalakath H, Rohrbeck L, Okamoto T, Bouillet P, Herold MJ, Goodall GJ, Jabbour AM, Ekert PG. Salmanidis M, et al. Among authors: sandow jj. Cell Death Differ. 2013 Oct;20(10):1370-80. doi: 10.1038/cdd.2013.92. Epub 2013 Jul 19. Cell Death Differ. 2013. PMID: 23872792 Free PMC article.
62 results