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Prolonged dopamine D3 receptor stimulation promotes dopamine transporter ubiquitination and degradation through a PKC-dependent mechanism.
Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Barroso-Chinea P, Afonso-Oramas D, Febles-Casquero A, Cruz-Muros I, Salas-Hernandez J, Mesa-Infante V, Rodriguez-Nuñez J, Gonzalez-Hernandez T. Luis-Ravelo D, et al. Pharmacol Res. 2021 Mar;165:105434. doi: 10.1016/j.phrs.2021.105434. Epub 2021 Jan 20. Pharmacol Res. 2021. PMID: 33484816
The dopamine transporter is differentially regulated after dopaminergic lesion.
Afonso-Oramas D, Cruz-Muros I, Barroso-Chinea P, Álvarez de la Rosa D, Castro-Hernández J, Salas-Hernández J, Giráldez T, González-Hernández T. Afonso-Oramas D, et al. Neurobiol Dis. 2010 Dec;40(3):518-30. doi: 10.1016/j.nbd.2010.07.012. Epub 2010 Aug 2. Neurobiol Dis. 2010. PMID: 20688165
Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease.
González-Hernández T, Cruz-Muros I, Afonso-Oramas D, Salas-Hernandez J, Castro-Hernandez J. González-Hernández T, et al. Front Neuroanat. 2010 Oct 20;4:140. doi: 10.3389/fnana.2010.00140. eCollection 2010. Front Neuroanat. 2010. PMID: 21079748 Free PMC article.
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system.
Barroso-Chinea P, Cruz-Muros I, Afonso-Oramas D, Castro-Hernández J, Salas-Hernández J, Chtarto A, Luis-Ravelo D, Humbert-Claude M, Tenenbaum L, González-Hernández T. Barroso-Chinea P, et al. Neurobiol Dis. 2016 Apr;88:44-54. doi: 10.1016/j.nbd.2016.01.002. Epub 2016 Jan 9. Neurobiol Dis. 2016. PMID: 26777664 Free article.
Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease.
Luis-Ravelo D, Estévez-Silva H, Barroso-Chinea P, Afonso-Oramas D, Salas-Hernández J, Rodríguez-Núñez J, Acevedo-Arozena A, Marcellino D, González-Hernández T. Luis-Ravelo D, et al. Exp Neurol. 2018 Jan;299(Pt A):137-147. doi: 10.1016/j.expneurol.2017.10.019. Epub 2017 Oct 19. Exp Neurol. 2018. PMID: 29056363
DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Barroso-Chinea P, Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Salas-Hernandez J, Rodriguez-Nuñez J, Febles-Casquero A, Cruz-Muros I, Afonso-Oramas D, Abreu-Gonzalez P, Moratalla R, Millan MJ, Gonzalez-Hernandez T. Barroso-Chinea P, et al. Autophagy. 2020 Jul;16(7):1279-1295. doi: 10.1080/15548627.2019.1668606. Epub 2019 Oct 2. Autophagy. 2020. PMID: 31538542 Free PMC article.
Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease.
Mesa-Infante V, Afonso-Oramas D, Salas-Hernández J, Rodríguez-Núñez J, Barroso-Chinea P. Mesa-Infante V, et al. Among authors: salas hernandez j. Mol Cell Neurosci. 2022 Jan;118:103684. doi: 10.1016/j.mcn.2021.103684. Epub 2021 Nov 23. Mol Cell Neurosci. 2022. PMID: 34826608 Free article.
38 results