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GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.
medRxiv [Preprint]. 2023 Oct 5:2023.10.04.23296543. doi: 10.1101/2023.10.04.23296543.
medRxiv. 2023.
PMID: 37873414
Free PMC article.
Preprint.
Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove.
Tsakok T, Saklatvala J, Rispens T, Loeff FC, de Vries A, Allen MH, Barbosa IA, Baudry D, Dasandi T, Duckworth M, Meynell F, Russell A, Chapman A, McBride S, McKenna K, Perera G, Ramsay H, Ramesh R, Sands K, Shipman A; Biomarkers of Systemic Treatment Outcomes in Psoriasis (BSTOP) Study Group; Burden AD, Griffiths CE, Reynolds NJ, Warren RB, Mahil S, Barker J, Dand N, Smith C, Simpson MA.
Tsakok T, et al.
JCI Insight. 2023 Feb 22;8(4):e156643. doi: 10.1172/jci.insight.156643.
JCI Insight. 2023.
PMID: 36810251
Free PMC article.
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Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies.
Saklatvala JR, Hanscombe KB, Mahil SK, Tsoi LC, Elder JT, Barker JN, Simpson MA, Smith CH, Dand N.
Saklatvala JR, et al.
J Invest Dermatol. 2023 Aug;143(8):1598-1601.e10. doi: 10.1016/j.jid.2023.02.010. Epub 2023 Mar 3.
J Invest Dermatol. 2023.
PMID: 36870556
Free PMC article.
No abstract available.
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Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria.
McSweeney SM, Saklatvala J, Rispoli R, Ganier C, Woszczek G, Thomas L, Hveem K, Løset M, Dand N, Tziotzios C, Simpson M, McGrath JA.
McSweeney SM, et al.
J Allergy Clin Immunol. 2024 Feb;153(2):521-526.e11. doi: 10.1016/j.jaci.2023.08.033. Epub 2023 Sep 9.
J Allergy Clin Immunol. 2024.
PMID: 37690594
Free article.
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Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research- an inter-disciplinary perspective.
Ramessur R, Dand N, Langan SM, Saklatvala J, Fritzsche MC, Holland S, Arents BWM, McAteer H, Proctor A, McMahon D, Greenwood M, Buyx AM, Messer T, Weiler N, Hicks A, Hecht P, Weidinger S, Ndlovu MN, Chengliang D, Hübenthal M, Egeberg A, Paternoster L, Skov L, De Jong EMGJ, Middelkamp-Hup MA, Mahil SK, Barker JN, Flohr C, Brown SJ, Smith CH.
Ramessur R, et al.
Br J Dermatol. 2024 Feb 29:ljae080. doi: 10.1093/bjd/ljae080. Online ahead of print.
Br J Dermatol. 2024.
PMID: 38419411
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Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.
Mitchell BL, Saklatvala JR, Dand N, Hagenbeek FA, Li X, Min JL, Thomas L, Bartels M, Jan Hottenga J, Lupton MK, Boomsma DI, Dong X, Hveem K, Løset M, Martin NG, Barker JN, Han J, Smith CH, Rentería ME, Simpson MA.
Mitchell BL, et al. Among authors: saklatvala jr.
Nat Commun. 2022 Feb 7;13(1):702. doi: 10.1038/s41467-022-28252-5.
Nat Commun. 2022.
PMID: 35132056
Free PMC article.
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Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.
Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA.
Tziotzios C, et al. Among authors: saklatvala jr.
Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.
Nat Commun. 2019.
PMID: 30850646
Free PMC article.
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Text-mined phenotype annotation and vector-based similarity to improve identification of similar phenotypes and causative genes in monogenic disease patients.
Saklatvala JR, Dand N, Simpson MA.
Saklatvala JR, et al.
Hum Mutat. 2018 May;39(5):643-652. doi: 10.1002/humu.23413. Epub 2018 Mar 15.
Hum Mutat. 2018.
PMID: 29460986
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