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Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor.
Liapakis G, Karageorgos V, Andreadelis I, Holz GG, Dermitzaki E, Kordopati GG, Stylos EΚ, Spyridaki K, Poulaki S, Ntountaniotis D, Sakellaris S, Vanioti M, Kostagianni A, Marousis KD, Leonis G, Kokotos G, Venihaki M, Spyroulias GA, Tselios T, Margioris A, Tzakos AG, Mavromoustakos T. Liapakis G, et al. Among authors: sakellaris s. Amino Acids. 2020 Sep;52(9):1337-1351. doi: 10.1007/s00726-020-02895-4. Epub 2020 Sep 29. Amino Acids. 2020. PMID: 32996057 Free PMC article.
Selective antagonism of CRF1 receptor by a substituted pyrimidine.
Sakellaris S, Matsoukas MT, Karageorgos V, Poulaki S, Kuppast B, Margioris A, Venihaki M, Fahmy H, Liapakis G. Sakellaris S, et al. Hormones (Athens). 2019 Jun;18(2):215-221. doi: 10.1007/s42000-019-00105-9. Epub 2019 Apr 12. Hormones (Athens). 2019. PMID: 30980254
Design, synthesis, structural optimization, SAR, in silico prediction of physicochemical properties and pharmacological evaluation of novel & potent thiazolo[4,5-d]pyrimidine corticotropin releasing factor (CRF) receptor antagonists.
Islam MR, Teleb M, Karageorgos V, Sakellaris S, Papadopoulos M, Pirmettis I, Fronczek FR, Liapakis G, Fahmy H. Islam MR, et al. Among authors: sakellaris s. Eur J Pharm Sci. 2022 Feb 1;169:106084. doi: 10.1016/j.ejps.2021.106084. Epub 2021 Nov 29. Eur J Pharm Sci. 2022. PMID: 34856350 Free article.