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eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T. Kashiwagi K, et al. Among authors: sakamoto a. Nat Commun. 2021 Dec 7;12(1):7102. doi: 10.1038/s41467-021-27337-x. Nat Commun. 2021. PMID: 34876589 Free PMC article.
Structural basis for eIF2B inhibition in integrated stress response.
Kashiwagi K, Yokoyama T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Shirouzu M, Ito T. Kashiwagi K, et al. Among authors: sakamoto a. Science. 2019 May 3;364(6439):495-499. doi: 10.1126/science.aaw4104. Science. 2019. PMID: 31048492
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D. Zyryanova AF, et al. Among authors: sakamoto a. Mol Cell. 2021 Jan 7;81(1):88-103.e6. doi: 10.1016/j.molcel.2020.10.031. Epub 2020 Nov 20. Mol Cell. 2021. PMID: 33220178 Free PMC article.
HCV IRES Captures an Actively Translating 80S Ribosome.
Yokoyama T, Machida K, Iwasaki W, Shigeta T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Harada Y, Shigematsu H, Shirouzu M, Tadakuma H, Imataka H, Ito T. Yokoyama T, et al. Among authors: sakamoto a. Mol Cell. 2019 Jun 20;74(6):1205-1214.e8. doi: 10.1016/j.molcel.2019.04.022. Epub 2019 May 9. Mol Cell. 2019. PMID: 31080011 Free article.
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.
Iwasaki S, Iwasaki W, Takahashi M, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T, Ingolia NT. Iwasaki S, et al. Among authors: sakamoto a. Mol Cell. 2019 Feb 21;73(4):738-748.e9. doi: 10.1016/j.molcel.2018.11.026. Epub 2018 Dec 27. Mol Cell. 2019. PMID: 30595437 Free PMC article.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: sakamoto a. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.
Saito K, Kigawa T, Koshiba S, Sato K, Matsuo Y, Sakamoto A, Takagi T, Shirouzu M, Yabuki T, Nunokawa E, Seki E, Matsuda T, Aoki M, Miyata Y, Hirakawa N, Inoue M, Terada T, Nagase T, Kikuno R, Nakayama M, Ohara O, Tanaka A, Yokoyama S. Saito K, et al. Among authors: sakamoto a. Structure. 2004 Sep;12(9):1719-28. doi: 10.1016/j.str.2004.07.012. Structure. 2004. PMID: 15341735 Free article.
1,862 results