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Impact of microsampling on toxicological evaluation in rodent safety studies.
Takahashi K, Hattori N, Yokoyama H, Jinno F, Ohtsuka H, Nakai K, Takumi A, Shibui Y, Yamaguchi K, Shimazaki T, Tanaka Y, Saito K, Kobayashi A, Saito Y. Takahashi K, et al. Among authors: saito k, saito y. J Appl Toxicol. 2024 Jan;44(1):118-128. doi: 10.1002/jat.4523. Epub 2023 Aug 7. J Appl Toxicol. 2024. PMID: 37548051 Review.
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database.
Adachi K, Ohyama K, Tanaka Y, Sato T, Murayama N, Shimizu M, Saito Y, Yamazaki H. Adachi K, et al. Among authors: saito y. Drug Metab Pharmacokinet. 2023 Apr;49:100486. doi: 10.1016/j.dmpk.2022.100486. Epub 2022 Dec 7. Drug Metab Pharmacokinet. 2023. PMID: 36746706
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6.
Shimizu M, Uehara S, Ohyama K, Nishimura H, Tanaka Y, Saito Y, Suemizu H, Yoshida S, Yamazaki H. Shimizu M, et al. Among authors: saito y. Drug Metab Dispos. 2023 Oct 25:DMD-AR-2023-001481. doi: 10.1124/dmd.123.001481. Online ahead of print. Drug Metab Dispos. 2023. PMID: 37879849 Free article.
9,427 results