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The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.
Kaneda A, Seike T, Danjo T, Nakajima T, Otsubo N, Yamaguchi D, Tsuji Y, Hamaguchi K, Yasunaga M, Nishiya Y, Suzuki M, Saito JI, Yatsunami R, Nakamura S, Sekido Y, Mori K. Kaneda A, et al. Among authors: saito ji. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415. eCollection 2020. Am J Cancer Res. 2020. PMID: 33415007 Free PMC article.
The structure of L-amino-acid ligase from Bacillus licheniformis.
Suzuki M, Takahashi Y, Noguchi A, Arai T, Yagasaki M, Kino K, Saito J. Suzuki M, et al. Acta Crystallogr D Biol Crystallogr. 2012 Nov;68(Pt 11):1535-40. doi: 10.1107/S0907444912038103. Epub 2012 Oct 13. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 23090402
Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers.
Yamamoto K, Tamura T, Henmi K, Kuboyama T, Yanagisawa A, Matsubara M, Takahashi Y, Suzuki M, Saito JI, Ueno K, Shuto S. Yamamoto K, et al. Among authors: saito ji. J Med Chem. 2018 Nov 21;61(22):10067-10083. doi: 10.1021/acs.jmedchem.8b01200. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30351933
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.
Yamamoto K, Tamura T, Nakamura R, Hosoe S, Matsubara M, Nagata K, Kodaira H, Uemori T, Takahashi Y, Suzuki M, Saito JI, Ueno K, Shuto S. Yamamoto K, et al. Among authors: saito ji. Bioorg Med Chem. 2019 Nov 15;27(22):115122. doi: 10.1016/j.bmc.2019.115122. Epub 2019 Sep 16. Bioorg Med Chem. 2019. PMID: 31623970 Free article.
siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Shinohara F, Oashi T, Harumoto T, Nishikawa T, Takayama Y, Miyagi H, Takahashi Y, Nakajima T, Sawada T, Koda Y, Makino A, Sato A, Hamaguchi K, Suzuki M, Yamamoto J, Tomari Y, Saito JI. Shinohara F, et al. Among authors: saito ji. RNA. 2021 Feb;27(2):163-173. doi: 10.1261/rna.073783.119. Epub 2020 Nov 11. RNA. 2021. PMID: 33177188 Free PMC article.
The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.
Kinosada H, Okada-Iwasaki R, Kunieda K, Suzuki-Imaizumi M, Takahashi Y, Miyagi H, Suzuki M, Motosawa K, Watanabe M, Mie M, Ishii T, Ishida H, Saito JI, Nakai R. Kinosada H, et al. Among authors: saito ji. Am J Cancer Res. 2021 Jan 1;11(1):264-276. eCollection 2021. Am J Cancer Res. 2021. PMID: 33520373 Free PMC article.
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