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A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. Xiong X, et al. Nat Struct Mol Biol. 2020 Jul;27(7):615-624. doi: 10.1038/s41594-020-0430-8. Epub 2020 Jun 1. Nat Struct Mol Biol. 2020. PMID: 32483339 Free PMC article.
Specialized insulin is used for chemical warfare by fish-hunting cone snails.
Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM. Safavi-Hemami H, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605914 Free PMC article.
Hormone-like peptides in the venoms of marine cone snails.
Robinson SD, Li Q, Bandyopadhyay PK, Gajewiak J, Yandell M, Papenfuss AT, Purcell AW, Norton RS, Safavi-Hemami H. Robinson SD, et al. Gen Comp Endocrinol. 2017 Apr 1;244:11-18. doi: 10.1016/j.ygcen.2015.07.012. Epub 2015 Aug 22. Gen Comp Endocrinol. 2017. PMID: 26301480 Free PMC article.
52 results