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Page 1
The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells.
Viñado AC, Calvo IA, Cenzano I, Olaverri D, Cocera M, San Martin-Uriz P, Romero JP, Vilas-Zornoza A, Vera L, Gomez-Cebrian N, Puchades-Carrasco L, Lisi-Vega LE, Apaolaza I, Valera P, Guruceaga E, Granero-Molto F, Ripalda-Cemborain P, Luck TJ, Bullinger L, Planes FJ, Rifon JJ, Méndez-Ferrer S, Yusuf RZ, Pardo-Saganta A, Prosper F, Saez B. Viñado AC, et al. Among authors: saez b. Leukemia. 2022 Aug;36(8):1969-1979. doi: 10.1038/s41375-022-01601-5. Epub 2022 May 26. Leukemia. 2022. PMID: 35618797 Free PMC article.
Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.
Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F. Agirre X, et al. Among authors: saez b. Mol Cancer Res. 2008 Dec;6(12):1830-40. doi: 10.1158/1541-7786.MCR-08-0167. Mol Cancer Res. 2008. PMID: 19074828
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. Gurumurthy S, et al. Among authors: saez b. Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Nature. 2010. PMID: 21124451 Free PMC article.
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Steinbicker AU, et al. Among authors: saez b. Blood. 2011 May 5;117(18):4915-23. doi: 10.1182/blood-2010-10-313064. Epub 2011 Mar 10. Blood. 2011. PMID: 21393479 Free PMC article.
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT. Sykes SM, et al. Among authors: saez b. Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. Cell. 2011. PMID: 21884932 Free PMC article.
Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT. Ferraro F, et al. Among authors: saez b. Sci Transl Med. 2011 Oct 12;3(104):104ra101. doi: 10.1126/scitranslmed.3002191. Sci Transl Med. 2011. PMID: 21998408 Free PMC article.
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT. Saez B, et al. Blood. 2014 Nov 6;124(19):2937-47. doi: 10.1182/blood-2014-08-593426. Epub 2014 Sep 8. Blood. 2014. PMID: 25202142 Free PMC article.
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT. Yu VW, et al. Among authors: saez b. J Exp Med. 2015 May 4;212(5):759-74. doi: 10.1084/jem.20141843. Epub 2015 Apr 27. J Exp Med. 2015. PMID: 25918341 Free PMC article.
99 results