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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, Wilson BG, Meyer MJ, Saenz-Vash V, Zhai H, Myer VE, Porter JA, Keen N, McLaughlin ME, Mickanin C, Roberts CW, Stegmeier F, Jagani Z. Hoffman GR, et al. Among authors: saenz vash v. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3128-33. doi: 10.1073/pnas.1316793111. Epub 2014 Feb 11. Proc Natl Acad Sci U S A. 2014. PMID: 24520176 Free PMC article.
Full-length myocilin protein is purified from mammalian cells as a dimer.
Katoli P, Godbole A, Romanowski MJ, Clark K, Meredith E, Saenz-Vash V, Wang YK, Lewicki N, Nguyen AA, Lynch JM. Katoli P, et al. Among authors: saenz vash v. Protein Expr Purif. 2018 Jul;147:38-48. doi: 10.1016/j.pep.2018.02.008. Epub 2018 Feb 21. Protein Expr Purif. 2018. PMID: 29475084
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L. Markljung E, et al. Among authors: saenz vash v. PLoS Biol. 2009 Dec;7(12):e1000256. doi: 10.1371/journal.pbio.1000256. Epub 2009 Dec 15. PLoS Biol. 2009. PMID: 20016685 Free PMC article.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A. Lynch JM, et al. Among authors: saenz vash v. J Biol Chem. 2018 Dec 28;293(52):20137-20156. doi: 10.1074/jbc.RA118.004325. Epub 2018 Nov 2. J Biol Chem. 2018. PMID: 30389787 Free PMC article.