Sadleir KR - Search Results

1

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.

Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Among authors: sadleir kr. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.

2

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. O'Connor T, et al. Among authors: sadleir kr. Neuron. 2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047. Neuron. 2008. PMID: 19109907 Free PMC article.

3

Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.

Sadleir KR, Vassar R. Sadleir KR, et al. J Biol Chem. 2012 Mar 2;287(10):7224-35. doi: 10.1074/jbc.M111.333914. Epub 2012 Jan 5. J Biol Chem. 2012. PMID: 22223639 Free PMC article.

4

Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice.

Perez SE, Nadeem M, Sadleir KR, Matras J, Kelley CM, Counts SE, Vassar R, Mufson EJ. Perez SE, et al. Among authors: sadleir kr. Int J Physiol Pathophysiol Pharmacol. 2012;4(3):115-27. Epub 2012 Sep 20. Int J Physiol Pathophysiol Pharmacol. 2012. PMID: 23071869 Free PMC article.

5

The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.

Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. Kandalepas PC, et al. Among authors: sadleir kr. Acta Neuropathol. 2013 Sep;126(3):329-52. doi: 10.1007/s00401-013-1152-3. Epub 2013 Jul 3. Acta Neuropathol. 2013. PMID: 23820808 Free PMC article.

6

Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.

Sadleir KR, Bennett DA, Schneider JA, Vassar R. Sadleir KR, et al. Curr Alzheimer Res. 2013 Oct;10(8):785-9. doi: 10.2174/15672050113109990152. Curr Alzheimer Res. 2013. PMID: 23919773 Free PMC article.

7

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Sadleir KR, et al. PLoS One. 2014 Jul 3;9(7):e101643. doi: 10.1371/journal.pone.0101643. eCollection 2014. PLoS One. 2014. PMID: 24992504 Free PMC article.

8

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.

Sadleir KR, Eimer WA, Cole SL, Vassar R. Sadleir KR, et al. Mol Neurodegener. 2015 Jan 7;10:1. doi: 10.1186/1750-1326-10-1. Mol Neurodegener. 2015. PMID: 25567526 Free PMC article.

9

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.

Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Sadleir KR, et al. Acta Neuropathol. 2016 Aug;132(2):235-256. doi: 10.1007/s00401-016-1558-9. Epub 2016 Mar 18. Acta Neuropathol. 2016. PMID: 26993139 Free PMC article.

10

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.

Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C. Rocchi A, et al. PLoS Genet. 2017 Aug 14;13(8):e1006962. doi: 10.1371/journal.pgen.1006962. eCollection 2017 Aug. PLoS Genet. 2017. PMID: 28806762 Free PMC article.

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