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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: sabbasani vr. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.
Rapid 13C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH.
Adelabu I, Ettedgui J, Joshi SM, Nantogma S, Chowdhury MRH, McBride S, Theis T, Sabbasani VR, Chandrasekhar M, Sail D, Yamamoto K, Swenson RE, Krishna MC, Goodson BM, Chekmenev EY. Adelabu I, et al. Among authors: sabbasani vr. Anal Chem. 2022 Oct 4;94(39):13422-13431. doi: 10.1021/acs.analchem.2c02160. Epub 2022 Sep 22. Anal Chem. 2022. PMID: 36136056 Free PMC article.
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Caianiello DF, et al. Among authors: sabbasani vr. Nat Chem Biol. 2021 Sep;17(9):947-953. doi: 10.1038/s41589-021-00851-1. Epub 2021 Aug 19. Nat Chem Biol. 2021. PMID: 34413525
17 results