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Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia. The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH).
de Sauvage Nolting PR, Buirma RJ, Hutten BA, Kastelein JJ; Dutch ExPRESS investigators Group. de Sauvage Nolting PR, et al. Atherosclerosis. 2002 Oct;164(2):347-54. doi: 10.1016/s0021-9150(02)00111-9. Atherosclerosis. 2002. PMID: 12204807 Clinical Trial.
A total of 508 FH patients were included and mean LDL-C levels (8.37+/-2.12 mmol l(-1)) were severely elevated. After a washout period of 6 weeks, all patients started monotherapy with 80 mg simvastatin. Remarkably, LDL-C reduction was dependent on baseline LDL-C levels ra …
A total of 508 FH patients were included and mean LDL-C levels (8.37+/-2.12 mmol l(-1)) were severely elevated. After a washout period of 6 …
Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial.
Saevarsdottir S, Wallin H, Seddighzadeh M, Ernestam S, Geborek P, Petersson IF, Bratt J, van Vollenhoven RF; SWEFOT Trial Investigators Group. Saevarsdottir S, et al. Ann Rheum Dis. 2011 Mar;70(3):469-75. doi: 10.1136/ard.2010.139212. Epub 2010 Dec 13. Ann Rheum Dis. 2011. PMID: 21149498 Clinical Trial.
METHODS: In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until the 3-4- month visit. ...
METHODS: In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 co …
Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a full economic analysis of a multicenter randomized controlled trial based on US costs.
Doig GS, Simpson F; Early PN Trial Investigators Group. Doig GS, et al. Clinicoecon Outcomes Res. 2013 Jul 22;5:369-79. doi: 10.2147/CEOR.S48821. Print 2013. Clinicoecon Outcomes Res. 2013. PMID: 23901287 Free PMC article.
PURPOSE: The provision of early enteral (gut) nutrition to critically ill patients, started within 24 hours of injury or intensive care unit admission, is accepted to improve health outcomes. ...
PURPOSE: The provision of early enteral (gut) nutrition to critically ill patients, started within 24 hours of injury or intensive ca …