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Page 1
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.
Bos PH, Lowry ER, Costa J, Thams S, Garcia-Diaz A, Zask A, Wichterle H, Stockwell BR. Bos PH, et al. Cell Chem Biol. 2019 Dec 19;26(12):1703-1715.e37. doi: 10.1016/j.chembiol.2019.10.005. Epub 2019 Oct 31. Cell Chem Biol. 2019. PMID: 31676236 Free PMC article.
K-RasG12D Has a Potential Allosteric Small Molecule Binding Site.
Feng H, Zhang Y, Bos PH, Chambers JM, Dupont MM, Stockwell BR. Feng H, et al. Biochemistry. 2019 May 28;58(21):2542-2554. doi: 10.1021/acs.biochem.8b01300. Epub 2019 May 14. Biochemistry. 2019. PMID: 31042025 Free PMC article.
Multivalent Small-Molecule Pan-RAS Inhibitors.
Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR. Welsch ME, et al. Cell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006. Cell. 2017. PMID: 28235199 Free PMC article.
Regulation of ferroptotic cancer cell death by GPX4.
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Yang WS, et al. Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010. Cell. 2014. PMID: 24439385 Free PMC article.