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Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress.
Madaris TR, Venkatesan M, Maity S, Stein MC, Vishnu N, Venkateswaran MK, Davis JG, Ramachandran K, Uthayabalan S, Allen C, Osidele A, Stanley K, Bigham NP, Bakewell TM, Narkunan M, Le A, Karanam V, Li K, Mhapankar A, Norton L, Ross J, Aslam MI, Reeves WB, Singh BB, Caplan J, Wilson JJ, Stathopulos PB, Baur JA, Madesh M. Madaris TR, et al. Cell Rep. 2023 Mar 28;42(3):112155. doi: 10.1016/j.celrep.2023.112155. Epub 2023 Feb 27. Cell Rep. 2023. PMID: 36857182 Free PMC article.
NAD precursors cycle between host tissues and the gut microbiome.
Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, Davidson SM, Thaiss CA, Migaud ME, Rabinowitz JD, Baur JA. Chellappa K, et al. Cell Metab. 2022 Dec 6;34(12):1947-1959.e5. doi: 10.1016/j.cmet.2022.11.004. Cell Metab. 2022. PMID: 36476934 Free PMC article.
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. Murashige D, et al. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7. doi: 10.1016/j.cmet.2022.09.008. Epub 2022 Oct 11. Cell Metab. 2022. PMID: 36223763 Free PMC article.
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T. Choa R, et al. Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893. Science. 2021. PMID: 34326208 Free PMC article.
Quantitative Fluxomics of Circulating Metabolites.
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Hui S, et al. Cell Metab. 2020 Oct 6;32(4):676-688.e4. doi: 10.1016/j.cmet.2020.07.013. Epub 2020 Aug 12. Cell Metab. 2020. PMID: 32791100 Free PMC article.