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TK216 targets microtubules in Ewing sarcoma cells.
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG. Povedano JM, et al. Cell Chem Biol. 2022 Aug 18;29(8):1325-1332.e4. doi: 10.1016/j.chembiol.2022.06.002. Epub 2022 Jul 7. Cell Chem Biol. 2022. PMID: 35803262 Free PMC article.
Delineating a serotonin 1B receptor circuit for appetite suppression in mice.
Li L, Wyler SC, León-Mercado LA, Xu B, Oh Y, Swati, Chen X, Wan R, Arnold AG, Jia L, Wang G, Nautiyal K, Hen R, Sohn JW, Liu C. Li L, et al. J Exp Med. 2022 Aug 1;219(8):e20212307. doi: 10.1084/jem.20212307. Epub 2022 Jul 7. J Exp Med. 2022. PMID: 35796804 Free PMC article.
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress.
Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV. Liu X, et al. Nat Cancer. 2022 Jul;3(7):866-884. doi: 10.1038/s43018-022-00389-8. Epub 2022 Jun 2. Nat Cancer. 2022. PMID: 35654861 Free PMC article.
71 results