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Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D. Altman PX, et al. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.580058. doi: 10.1101/2024.02.13.580058. bioRxiv. 2024. PMID: 38405899 Free PMC article. Preprint.
An intramolecular macrocyclase in plant ribosomal peptide biosynthesis.
Mydy LS, Hungerford J, Chigumba DN, Konwerski JR, Jantzi SC, Wang D, Smith JL, Kersten RD. Mydy LS, et al. Nat Chem Biol. 2024 Apr;20(4):530-540. doi: 10.1038/s41589-024-01552-1. Epub 2024 Feb 14. Nat Chem Biol. 2024. PMID: 38355722 Free PMC article.
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane.
Saphire E, Salie ZL, Ke Z, Halfmann P, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel S, Hariharan C, Norris M, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook M, Doranz B, Crozier I, Hastie K, Kawaoka Y, Branco L, Kuhn J, Briggs J, Worwa G, Davis C, Ahmed R. Saphire E, et al. Res Sq [Preprint]. 2023 Dec 22:rs.3.rs-3722563. doi: 10.21203/rs.3.rs-3722563/v1. Res Sq. 2023. PMID: 38196595 Free PMC article. Preprint.
Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
Caffrey PJ, Eckenroth BE, Burkhart BW, Zatopek KM, McClung CM, Santangelo TJ, Doublié S, Gardner AF. Caffrey PJ, et al. J Biol Chem. 2024 Jan;300(1):105503. doi: 10.1016/j.jbc.2023.105503. Epub 2023 Nov 25. J Biol Chem. 2024. PMID: 38013090 Free PMC article.
Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai E, Murugan R, Binter Š, Burn Aschner C, Prieto K, Kassardjian A, Obraztsova AS, Kang RW, Flores-Garcia Y, Mathis-Torres S, Li K, Horn GQ, Huntwork RHC, Bolscher JM, de Bruijni MHC, Sauerwein R, Dennison SM, Tomaras GD, Zavala F, Kellam P, Wardemann H, Julien JP. Thai E, et al. Cell Rep. 2023 Nov 28;42(11):113330. doi: 10.1016/j.celrep.2023.113330. Epub 2023 Oct 28. Cell Rep. 2023. PMID: 38007690 Free PMC article.
155 results