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2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor.
Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B. Gillerman I, et al. Among authors: sevigny j. J Med Chem. 2014 Jul 24;57(14):5919-34. doi: 10.1021/jm401933c. Epub 2014 Jul 14. J Med Chem. 2014. PMID: 24972256
Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold.
Nadel Y, Lecka J, Gilad Y, Ben-David G, Förster D, Reiser G, Kenigsberg S, Camden J, Weisman GA, Senderowitz H, Sévigny J, Fischer B. Nadel Y, et al. Among authors: sevigny j. J Med Chem. 2014 Jun 12;57(11):4677-91. doi: 10.1021/jm500196c. Epub 2014 May 30. J Med Chem. 2014. PMID: 24846781 Free PMC article.
350 results