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Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Chan LN, et al. Nature. 2017 Feb 23;542(7642):479-483. doi: 10.1038/nature21076. Epub 2017 Feb 13. Nature. 2017. PMID: 28192788 Free PMC article.
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.
Romero-Camarero I, Jiang X, Natkunam Y, Lu X, Vicente-Dueñas C, Gonzalez-Herrero I, Flores T, Garcia JL, McNamara G, Kunder C, Zhao S, Segura V, Fontan L, Martínez-Climent JA, García-Criado FJ, Theis JD, Dogan A, Campos-Sánchez E, Green MR, Alizadeh AA, Cobaleda C, Sánchez-García I, Lossos IS. Romero-Camarero I, et al. Nat Commun. 2013;4:1338. doi: 10.1038/ncomms2334. Nat Commun. 2013. PMID: 23299888 Free PMC article.
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.
Green MR, Vicente-Dueñas C, Romero-Camarero I, Long Liu C, Dai B, González-Herrero I, García-Ramírez I, Alonso-Escudero E, Iqbal J, Chan WC, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jiménez R, Martínez-Climent JA, Criado FJ, Cenador MB, Zhao S, Natkunam Y, Lossos IS, Majeti R, Melnick A, Cobaleda C, Alizadeh AA, Sánchez-García I. Green MR, et al. Nat Commun. 2014 Jun 2;5:3904. doi: 10.1038/ncomms4904. Nat Commun. 2014. PMID: 24887457 Free PMC article.
Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.
Martín-Lorenzo A, Hauer J, Vicente-Dueñas C, Auer F, González-Herrero I, García-Ramírez I, Ginzel S, Thiele R, Constantinescu SN, Bartenhagen C, Dugas M, Gombert M, Schäfer D, Blanco O, Mayado A, Orfao A, Alonso-López D, Rivas Jde L, Cobaleda C, García-Cenador MB, García-Criado FJ, Sánchez-García I, Borkhardt A. Martín-Lorenzo A, et al. Cancer Discov. 2015 Dec;5(12):1328-43. doi: 10.1158/2159-8290.CD-15-0892. Epub 2015 Sep 25. Cancer Discov. 2015. PMID: 26408659
GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.
Auer F, Ingenhag D, Bhatia S, Enczmann J, Cobaleda C, Sanchez-Garcia I, Borkhardt A, Hauer J. Auer F, et al. Eur J Med Genet. 2016 Mar;59(3):166-72. doi: 10.1016/j.ejmg.2015.11.009. Epub 2015 Nov 26. Eur J Med Genet. 2016. PMID: 26626503 Review.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases.
Rodríguez-Hernández G, Hauer J, Martín-Lorenzo A, Schäfer D, Bartenhagen C, García-Ramírez I, Auer F, González-Herrero I, Ruiz-Roca L, Gombert M, Okpanyi V, Fischer U, Chen C, Dugas M, Bhatia S, Linka RM, Garcia-Suquia M, Rascón-Trincado MV, Garcia-Sanchez A, Blanco O, García-Cenador MB, García-Criado FJ, Cobaleda C, Alonso-López D, De Las Rivas J, Müschen M, Vicente-Dueñas C, Sánchez-García I, Borkhardt A. Rodríguez-Hernández G, et al. Cancer Res. 2017 Aug 15;77(16):4365-4377. doi: 10.1158/0008-5472.CAN-17-0701. Epub 2017 Jun 19. Cancer Res. 2017. PMID: 28630052
Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells.
Auer F, Ingenhag D, Pinkert S, Kracker S, Hacein-Bey-Abina S, Cavazzana M, Gombert M, Martin-Lorenzo A, Lin MH, Vicente-Dueñas C, Sánchez-García I, Borkhardt A, Hauer J. Auer F, et al. Oncotarget. 2017 Sep 7;8(44):75797-75807. doi: 10.18632/oncotarget.20563. eCollection 2017 Sep 29. Oncotarget. 2017. PMID: 29100269 Free PMC article.
Modeling the process of childhood ETV6-RUNX1 B-cell leukemias.
Rodríguez-Hernández G, Schäfer D, Gavilán A, Vicente-Dueñas C, Hauer J, Borkhardt A, Sánchez-García I. Rodríguez-Hernández G, et al. Oncotarget. 2017 Sep 27;8(60):102674-102680. doi: 10.18632/oncotarget.21281. eCollection 2017 Nov 24. Oncotarget. 2017. PMID: 29254279 Free PMC article. Review.
157 results