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Novel antiinflammatory biologics shaped by parasite-host coevolution.
Ryan SM, Ruscher R, Johnston WA, Pickering DA, Kennedy MW, Smith BO, Jones L, Buitrago G, Field MA, Esterman AJ, McHugh CP, Browne DJ, Cooper MM, Ryan RYM, Doolan DL, Engwerda CR, Miles K, Mitreva M, Croese J, Rahman T, Alexandrov K, Giacomin PR, Loukas A. Ryan SM, et al. Among authors: ruscher r. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2202795119. doi: 10.1073/pnas.2202795119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037362 Free PMC article.
IL-17A moonlighting in lung type 2 immunity.
Ruscher R, Giacomin PR. Ruscher R, et al. Mucosal Immunol. 2020 Nov;13(6):849-851. doi: 10.1038/s41385-020-0329-z. Epub 2020 Jul 29. Mucosal Immunol. 2020. PMID: 32728131 Free PMC article. No abstract available.
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.
Buitrago G, Pickering D, Ruscher R, Cobos Caceres C, Jones L, Cooper M, Van Waardenberg A, Ryan S, Miles K, Field M, Dredge K, Daly NL, Giacomin PR, Loukas A. Buitrago G, et al. Among authors: ruscher r. Transl Res. 2021 Jun;232:88-102. doi: 10.1016/j.trsl.2021.02.012. Epub 2021 Mar 4. Transl Res. 2021. PMID: 33676036 Free article.
Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells.
Cobos C, Bansal PS, Wilson DT, Jones L, Zhao G, Field MA, Eichenberger RM, Pickering DA, Ryan RYM, Ratnatunga CN, Miles JJ, Ruscher R, Giacomin PR, Navarro S, Loukas A, Daly NL. Cobos C, et al. Among authors: ruscher r. Front Med (Lausanne). 2022 Sep 9;9:934852. doi: 10.3389/fmed.2022.934852. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36186812 Free PMC article.
Expansible residence decentralizes immune homeostasis.
Wijeyesinghe S, Beura LK, Pierson MJ, Stolley JM, Adam OA, Ruscher R, Steinert EM, Rosato PC, Vezys V, Masopust D. Wijeyesinghe S, et al. Among authors: ruscher r. Nature. 2021 Apr;592(7854):457-462. doi: 10.1038/s41586-021-03351-3. Epub 2021 Mar 17. Nature. 2021. PMID: 33731934 Free PMC article.
21 results