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Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome.
Dinstag G, Shulman ED, Elis E, Ben-Zvi DS, Tirosh O, Maimon E, Meilijson I, Elalouf E, Temkin B, Vitkovsky P, Schiff E, Hoang DT, Sinha S, Nair NU, Lee JS, Schäffer AA, Ronai Z, Juric D, Apolo AB, Dahut WL, Lipkowitz S, Berger R, Kurzrock R, Papanicolau-Sengos A, Karzai F, Gilbert MR, Aldape K, Rajagopal PS, Beker T, Ruppin E, Aharonov R. Dinstag G, et al. Among authors: ruppin e. Med. 2023 Jan 13;4(1):15-30.e8. doi: 10.1016/j.medj.2022.11.001. Epub 2022 Dec 12. Med. 2023. PMID: 36513065 Free PMC article.
Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues.
Crawford DR, Sinha S, Nair NU, Ryan BM, Barnholtz-Sloan JS, Mount SM, Erez A, Aldape K, Castle PE, Rajagopal PS, Day CP, Schäffer AA, Ruppin E. Crawford DR, et al. Among authors: ruppin e. Cancers (Basel). 2022 Nov 29;14(23):5885. doi: 10.3390/cancers14235885. Cancers (Basel). 2022. PMID: 36497367 Free PMC article.
Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma.
Nair NU, Jiang Q, Wei JS, Misra VA, Morrow B, Kesserwan C, Hermida LC, Lee JS, Mian I, Zhang J, Lebensohn A, Miettinen M, Sengupta M, Khan J, Ruppin E, Hassan R. Nair NU, et al. Among authors: ruppin e. Cell Rep Med. 2023 Feb 21;4(2):100938. doi: 10.1016/j.xcrm.2023.100938. Epub 2023 Feb 10. Cell Rep Med. 2023. PMID: 36773602 Free PMC article.
The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure.
Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS. Wu VH, et al. Among authors: ruppin e. Nat Immunol. 2023 Aug;24(8):1318-1330. doi: 10.1038/s41590-023-01529-7. Epub 2023 Jun 12. Nat Immunol. 2023. PMID: 37308665 Free PMC article.
331 results