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Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development.
Miranda C, Ruiz-Picazo A, Pomares P, Gonzalez-Alvarez I, Bermejo M, Gonzalez-Alvarez M, Avdeef A, Cabrera-Pérez MÁ. Miranda C, et al. Among authors: ruiz picazo a. Pharmaceutics. 2022 Jan 13;14(1):182. doi: 10.3390/pharmaceutics14010182. Pharmaceutics. 2022. PMID: 35057075 Free PMC article.
Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen.
Cámara-Martinez I, Blechar JA, Ruiz-Picazo A, Garcia-Arieta A, Calandria C, Merino-Sanjuan V, Langguth P, Gonzalez-Alvarez M, Bermejo M, Al-Gousous J, Gonzalez-Alvarez I. Cámara-Martinez I, et al. Among authors: ruiz picazo a. Int J Pharm. 2022 Feb 25;614:121415. doi: 10.1016/j.ijpharm.2021.121415. Epub 2021 Dec 30. Int J Pharm. 2022. PMID: 34973409 Free article.
In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC.
Ruiz Picazo A, Martinez-Martinez MT, Colón-Useche S, Iriarte R, Sánchez-Dengra B, González-Álvarez M, García-Arieta A, González-Álvarez I, Bermejo M. Ruiz Picazo A, et al. Mol Pharm. 2018 Jun 4;15(6):2307-2315. doi: 10.1021/acs.molpharmaceut.8b00153. Epub 2018 May 17. Mol Pharm. 2018. PMID: 29746133 Clinical Trial.
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