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Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Astakhova TY, Timokhina EN, Serkov IV, Proshin AN, Soldatova YV, Poletaeva DA, Faingold II, Mumyatova VA, Terentiev AA, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Molecules. 2024 Jan 9;29(2):321. doi: 10.3390/molecules29020321. Molecules. 2024. PMID: 38257233 Free PMC article.
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Rudakova EV, Stupina TS, Terentiev AA, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Bioorg Chem. 2020 Jan;94:103387. doi: 10.1016/j.bioorg.2019.103387. Epub 2019 Oct 28. Bioorg Chem. 2020. PMID: 31735356
New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Astakhova TY, Rudakova EV, Proshin AN, Serkov IV, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Molecules. 2020 Aug 27;25(17):3915. doi: 10.3390/molecules25173915. Molecules. 2020. PMID: 32867324 Free PMC article.
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Faingold II, Poletaeva DA, Soldatova YV, Kotelnikova RA, Serkov IV, Ustinov AK, Proshin AN, Radchenko EV, Palyulin VA, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Molecules. 2020 Dec 12;25(24):5891. doi: 10.3390/molecules25245891. Molecules. 2020. PMID: 33322783 Free PMC article.
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands.
Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, Rudakova EV, Fisenko VP, Bovina EV, Richardson RJ. Bachurin SO, et al. Among authors: rudakova ev. Molecules. 2021 Sep 11;26(18):5527. doi: 10.3390/molecules26185527. Molecules. 2021. PMID: 34576998 Free PMC article.
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.
Makhaeva GF, Kovaleva NV, Boltneva NP, Rudakova EV, Lushchekina SV, Astakhova TY, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Korabecny J, Soukup O, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Molecules. 2022 Feb 4;27(3):1060. doi: 10.3390/molecules27031060. Molecules. 2022. PMID: 35164325 Free PMC article.
Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity.
Burgart YV, Makhaeva GF, Krasnykh OP, Borisevich SS, Agafonova NA, Kovaleva NV, Boltneva NP, Rudakova EV, Shchegolkov EV, Triandafilova GA, Gazizov DA, Serebryakova OG, Ulitko MV, Khursan SL, Saloutin VI, Richardson RJ. Burgart YV, et al. Among authors: rudakova ev. Molecules. 2022 Nov 9;27(22):7722. doi: 10.3390/molecules27227722. Molecules. 2022. PMID: 36431823 Free PMC article.
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Grishchenko MV, Lushchekina SV, Astakhova TY, Serebryakova OG, Timokhina EN, Zhilina EF, Shchegolkov EV, Ulitko MV, Radchenko EV, Palyulin VA, Burgart YV, Saloutin VI, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: rudakova ev. Int J Mol Sci. 2023 Jan 24;24(3):2285. doi: 10.3390/ijms24032285. Int J Mol Sci. 2023. PMID: 36768608 Free PMC article.
44 results