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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: rubinsztein dc. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.
Complex inhibitory effects of nitric oxide on autophagy.
Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. Mol Cell. 2011 Jul 8;43(1):19-32. doi: 10.1016/j.molcel.2011.04.029. Mol Cell. 2011. PMID: 21726807 Free PMC article.
PICALM modulates autophagy activity and tau accumulation.
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC. Moreau K, et al. Among authors: rubinsztein dc. Nat Commun. 2014 Sep 22;5:4998. doi: 10.1038/ncomms5998. Nat Commun. 2014. PMID: 25241929 Free PMC article.
Compromised autophagy and neurodegenerative diseases.
Menzies FM, Fleming A, Rubinsztein DC. Menzies FM, et al. Among authors: rubinsztein dc. Nat Rev Neurosci. 2015 Jun;16(6):345-57. doi: 10.1038/nrn3961. Nat Rev Neurosci. 2015. PMID: 25991442 Review.
443 results