Rubinsztein DC - Search Results

1

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Yanai A, et al. Among authors: rubinsztein dc. Nat Neurosci. 2006 Jun;9(6):824-31. doi: 10.1038/nn1702. Epub 2006 May 14. Nat Neurosci. 2006. PMID: 16699508 Free PMC article.

2

Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

Ravikumar B, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Mol Aspects Med. 2006 Oct-Dec;27(5-6):520-7. doi: 10.1016/j.mam.2006.08.008. Epub 2006 Sep 14. Mol Aspects Med. 2006. PMID: 16973207 Review.

3

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110. Epub 2008 Jul 18. Cell Death Differ. 2009. PMID: 18636076 Review.

4

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy.

Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2003 May 1;12(9):985-94. doi: 10.1093/hmg/ddg109. Hum Mol Genet. 2003. PMID: 12700167

5

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2004 Jun;36(6):585-95. doi: 10.1038/ng1362. Epub 2004 May 16. Nat Genet. 2004. PMID: 15146184

6

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

Webb JL, Ravikumar B, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. Int J Biochem Cell Biol. 2004 Dec;36(12):2541-50. doi: 10.1016/j.biocel.2004.02.003. Int J Biochem Cell Biol. 2004. PMID: 15325591

7

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2005 Jul;37(7):771-6. doi: 10.1038/ng1591. Epub 2005 Jun 26. Nat Genet. 2005. PMID: 15980862

8

Clearance of mutant aggregate-prone proteins by autophagy.

Ravikumar B, Sarkar S, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Methods Mol Biol. 2008;445:195-211. doi: 10.1007/978-1-59745-157-4_13. Methods Mol Biol. 2008. PMID: 18425452

9

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2002 May 1;11(9):1107-17. doi: 10.1093/hmg/11.9.1107. Hum Mol Genet. 2002. PMID: 11978769

10

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.

Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. J Cell Sci. 2008 May 15;121(Pt 10):1649-60. doi: 10.1242/jcs.025726. Epub 2008 Apr 22. J Cell Sci. 2008. PMID: 18430781 Free PMC article.

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