Roy PJ - Search Results

1

Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with anthelmintic potential.

Harrington S, Pyche J, Burns AR, Spalholz T, Ryan KT, Baker RJ, Ching J, Rufener L, Lautens M, Kulke D, Vernudachi A, Zamanian M, Deuther-Conrad W, Brust P, Roy PJ. Harrington S, et al. Among authors: roy pj. Nat Commun. 2023 Mar 31;14(1):1816. doi: 10.1038/s41467-023-37452-6. Nat Commun. 2023. PMID: 37002199 Free PMC article.

2

A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Kwok TC, Ricker N, Fraser R, Chan AW, Burns A, Stanley EF, McCourt P, Cutler SR, Roy PJ. Kwok TC, et al. Among authors: roy pj. Nature. 2006 May 4;441(7089):91-5. doi: 10.1038/nature04657. Nature. 2006. PMID: 16672971

3

High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.

Burns AR, Kwok TC, Howard A, Houston E, Johanson K, Chan A, Cutler SR, McCourt P, Roy PJ. Burns AR, et al. Among authors: roy pj. Nat Protoc. 2006;1(4):1906-14. doi: 10.1038/nprot.2006.283. Nat Protoc. 2006. PMID: 17487175

4

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ. Burns AR, et al. Among authors: roy pj. Nat Chem Biol. 2010 Jul;6(7):549-57. doi: 10.1038/nchembio.380. Epub 2010 May 30. Nat Chem Biol. 2010. PMID: 20512140

5

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G. Wallace IM, et al. Among authors: roy pj. Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018. Chem Biol. 2011. PMID: 22035796 Free PMC article.

6

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Luciani GM, et al. Among authors: roy pj. Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Nat Chem Biol. 2011. PMID: 22057127

7

Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.

Tharmalingam S, Burns AR, Roy PJ, Hampson DR. Tharmalingam S, et al. Among authors: roy pj. Neuropharmacology. 2012 Sep;63(4):667-74. doi: 10.1016/j.neuropharm.2012.05.029. Epub 2012 May 28. Neuropharmacology. 2012. PMID: 22652059

8

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Burns AR, et al. Among authors: roy pj. Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485. Nat Commun. 2015. PMID: 26108372 Free PMC article.

9

The novel nematicide wact-86 interacts with aldicarb to kill nematodes.

Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ. Burns AR, et al. Among authors: roy pj. PLoS Negl Trop Dis. 2017 Apr 5;11(4):e0005502. doi: 10.1371/journal.pntd.0005502. eCollection 2017 Apr. PLoS Negl Trop Dis. 2017. PMID: 28379972 Free PMC article.

10

The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules.

Kamal M, Moshiri H, Magomedova L, Han D, Nguyen KCQ, Yeo M, Knox J, Bagg R, Won AM, Szlapa K, Yip CM, Cummins CL, Hall DH, Roy PJ. Kamal M, et al. Among authors: roy pj. Nat Commun. 2019 Sep 2;10(1):3938. doi: 10.1038/s41467-019-11908-0. Nat Commun. 2019. PMID: 31477732 Free PMC article.

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