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The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.
Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H. Tsuda M, et al. Among authors: roy n. J Clin Invest. 2018 Aug 1;128(8):3475-3489. doi: 10.1172/JCI94287. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 30010625 Free PMC article.
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. von Figura G, et al. Among authors: roy n. Nat Cell Biol. 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23. Nat Cell Biol. 2014. PMID: 24561622 Free PMC article.
Regulation of Cellular Identity in Cancer.
Roy N, Hebrok M. Roy N, et al. Dev Cell. 2015 Dec 21;35(6):674-84. doi: 10.1016/j.devcel.2015.12.001. Dev Cell. 2015. PMID: 26702828 Free PMC article. Review.
p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.
Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM. Hendley AM, et al. Among authors: roy n. Cancer Res. 2016 Jun 1;76(11):3351-63. doi: 10.1158/0008-5472.CAN-15-2268. Epub 2016 Mar 31. Cancer Res. 2016. PMID: 27032419 Free PMC article.
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Laklai H, et al. Among authors: roy n. Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18. Nat Med. 2016. PMID: 27089513 Free PMC article.
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. Roy N, et al. Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116. Genes Dev. 2016. PMID: 28087712 Free PMC article.
Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.
Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. Ivry SL, et al. Among authors: roy n. Clin Cancer Res. 2017 Aug 15;23(16):4865-4874. doi: 10.1158/1078-0432.CCR-16-2987. Epub 2017 Apr 19. Clin Cancer Res. 2017. PMID: 28424202 Free PMC article.
Atypical flat lesions derive from pancreatic acinar cells.
von Figura G, Fahrenkrog-Petersen L, Hidalgo-Sastre A, Hartmann D, Hüser N, Schmid RM, Hebrok M, Roy N, Esposito I. von Figura G, et al. Among authors: roy n. Pancreatology. 2017 May-Jun;17(3):350-353. doi: 10.1016/j.pan.2017.04.014. Epub 2017 Apr 25. Pancreatology. 2017. PMID: 28473229 Free PMC article.
Replication confers β cell immaturity.
Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Puri S, et al. Among authors: roy n, roy r. Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0. Nat Commun. 2018. PMID: 29396395 Free PMC article.
1,740 results