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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
Schütz C, Ho DK, Hamed MM, Abdelsamie AS, Röhrig T, Herr C, Kany AM, Rox K, Schmelz S, Siebenbürger L, Wirth M, Börger C, Yahiaoui S, Bals R, Scrima A, Blankenfeldt W, Horstmann JC, Christmann R, Murgia X, Koch M, Berwanger A, Loretz B, Hirsch AKH, Hartmann RW, Lehr CM, Empting M. Schütz C, et al. Among authors: rox k. Adv Sci (Weinh). 2021 Jun;8(12):e2004369. doi: 10.1002/advs.202004369. Epub 2021 Mar 18. Adv Sci (Weinh). 2021. PMID: 34165899 Free PMC article.
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy.
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, Krull J, van den Heuvel J, Vassort A, Sordello S, Hamed MM, Elgaher WAM, Herrmann J, Hartmann RW, Müller R, Brönstrup M. Testolin G, et al. Among authors: rox k. Chem Sci. 2019 Dec 10;11(5):1316-1334. doi: 10.1039/c9sc04769g. Chem Sci. 2019. PMID: 34123255 Free PMC article.
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Hamed MM, Abdelsamie AS, Rox K, Schütz C, Kany AM, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña JM, Jahn D, Rademacher J, Ringshausen FC, Cramer N, Tümmler B, Hirsch AKH, Hartmann RW, Empting M. Hamed MM, et al. Among authors: rox k. Adv Sci (Weinh). 2023 Feb;10(5):e2204443. doi: 10.1002/advs.202204443. Epub 2023 Jan 3. Adv Sci (Weinh). 2023. PMID: 36596691 Free PMC article.
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
Le P, Kunold E, Macsics R, Rox K, Jennings MC, Ugur I, Reinecke M, Chaves-Moreno D, Hackl MW, Fetzer C, Mandl FAM, Lehmann J, Korotkov VS, Hacker SM, Kuster B, Antes I, Pieper DH, Rohde M, Wuest WM, Medina E, Sieber SA. Le P, et al. Among authors: rox k. Nat Chem. 2020 Feb;12(2):145-158. doi: 10.1038/s41557-019-0378-7. Epub 2019 Dec 16. Nat Chem. 2020. PMID: 31844194 Free PMC article.
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry.
Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Le Goffic R, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eléouët JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T. Blockus S, et al. Among authors: rox k. Antiviral Res. 2020 May;177:104774. doi: 10.1016/j.antiviral.2020.104774. Epub 2020 Mar 18. Antiviral Res. 2020. PMID: 32197980 Free article.
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