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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. Maruggi G, et al. Among authors: rowles a. Mol Ther. 2022 May 4;30(5):1897-1912. doi: 10.1016/j.ymthe.2022.01.001. Epub 2022 Jan 3. Mol Ther. 2022. PMID: 34990810 Free PMC article. Clinical Trial.
Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs.
Sokal DM, McSloy A, Donegà M, Kirk J, Colas RA, Dolezalova N, Gomez EA, Gupta I, Fjordbakk CT, Ouchouche S, Matteucci PB, Schlegel K, Bashirullah R, Werling D, Harman K, Rowles A, Yazicioglu RF, Dalli J, Chew DJ, Perkins JD. Sokal DM, et al. Among authors: rowles a. Front Immunol. 2021 Mar 29;12:649786. doi: 10.3389/fimmu.2021.649786. eCollection 2021. Front Immunol. 2021. PMID: 33859641 Free PMC article.
Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.
Gupta I, Cassará AM, Tarotin I, Donega M, Miranda JA, Sokal DM, Ouchouche S, Dopson W, Matteucci P, Neufeld E, Schiefer MA, Rowles A, McGill P, Perkins J, Dolezalova N, Saeb-Parsy K, Kuster N, Yazicioglu RF, Witherington J, Chew DJ. Gupta I, et al. Among authors: rowles a. Commun Biol. 2020 Oct 16;3(1):577. doi: 10.1038/s42003-020-01299-0. Commun Biol. 2020. PMID: 33067560 Free PMC article.
Human-relevant near-organ neuromodulation of the immune system via the splenic nerve.
Donegà M, Fjordbakk CT, Kirk J, Sokal DM, Gupta I, Hunsberger GE, Crawford A, Cook S, Viscasillas J, Stathopoulou TR, Miranda JA, Dopson WJ, Goodwin D, Rowles A, McGill P, McSloy A, Werling D, Witherington J, Chew DJ, Perkins JD. Donegà M, et al. Among authors: rowles a. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2025428118. doi: 10.1073/pnas.2025428118. Proc Natl Acad Sci U S A. 2021. PMID: 33972441 Free PMC article.
21 results