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Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
Schmaus A, Rothley M, Schreiber C, Möller S, Roßwag S, Franz S, Garvalov BK, Thiele W, Spataro S, Herskind C, Prunotto M, Anderegg U, Schnabelrauch M, Sleeman J. Schmaus A, et al. Among authors: rothley m. Matrix Biol. 2022 May;109:173-191. doi: 10.1016/j.matbio.2022.04.001. Epub 2022 Apr 8. Matrix Biol. 2022. PMID: 35405271
Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis.
Schreiber C, Gruber A, Roßwag S, Saraswati S, Harkins S, Thiele W, Foroushani ZH, Munding N, Schmaus A, Rothley M, Dimmler A, Tanaka M, Garvalov BK, Sleeman JP. Schreiber C, et al. Among authors: rothley m. Cancer Lett. 2022 May 1;533:215600. doi: 10.1016/j.canlet.2022.215600. Epub 2022 Feb 15. Cancer Lett. 2022. PMID: 35181478
Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleeman JP. Schreiber C, et al. Among authors: rothley m. PLoS Genet. 2019 Jun 27;15(6):e1008216. doi: 10.1371/journal.pgen.1008216. eCollection 2019 Jun. PLoS Genet. 2019. PMID: 31246957 Free PMC article.
IER2-induced senescence drives melanoma invasion through osteopontin.
Kyjacova L, Saup R, Rönsch K, Wallbaum S, Dukowic-Schulze S, Foss A, Scherer SD, Rothley M, Neeb A, Grau N, Thiele W, Thaler S, Cremers N, Sticht C, Gretz N, Garvalov BK, Utikal J, Sleeman JP. Kyjacova L, et al. Among authors: rothley m. Oncogene. 2021 Nov;40(47):6494-6512. doi: 10.1038/s41388-021-02027-6. Epub 2021 Oct 5. Oncogene. 2021. PMID: 34611309 Free PMC article.
Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats.
Thiele W, Rothley M, Teller N, Jung N, Bulat B, Plaumann D, Vanderheiden S, Schmaus A, Cremers N, Göppert B, Dimmler A, Eschbach V, Quagliata L, Thaler S, Marko D, Bräse S, Sleeman JP. Thiele W, et al. Among authors: rothley m. Carcinogenesis. 2013 Dec;34(12):2804-13. doi: 10.1093/carcin/bgt291. Epub 2013 Aug 23. Carcinogenesis. 2013. PMID: 23975834
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