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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz EJ, Pinto-Fernandez A, Turnbull AP, Lan L, Charlton TM, Scott HC, Damianou A, Vere G, Riising EM, Da Costa C, Krajewski WW, Guerin D, Kearns JD, Ioannidis S, Katz M, McKinnon C, O'Connell J, Moncaut N, Rosewell I, Nye E, Jones N, Heride C, Gersch M, Wu M, Dinsmore CJ, Hammonds TR, Kim S, Komander D, Urbe S, Clague MJ, Kessler BM, Behrens A. Ruiz EJ, et al. Among authors: rosewell i. Elife. 2021 Oct 12;10:e71596. doi: 10.7554/eLife.71596. Elife. 2021. PMID: 34636321 Free PMC article.
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Giampazolias E, Schulz O, Lim KHJ, Rogers NC, Chakravarty P, Srinivasan N, Gordon O, Cardoso A, Buck MD, Poirier EZ, Canton J, Zelenay S, Sammicheli S, Moncaut N, Varsani-Brown S, Rosewell I, Reis e Sousa C. Giampazolias E, et al. Among authors: rosewell i. Cell. 2021 Jul 22;184(15):4016-4031.e22. doi: 10.1016/j.cell.2021.05.021. Epub 2021 Jun 2. Cell. 2021. PMID: 34081922 Free PMC article.
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP. Pollard PJ, et al. Among authors: rosewell i. Cancer Cell. 2007 Apr;11(4):311-9. doi: 10.1016/j.ccr.2007.02.005. Cancer Cell. 2007. PMID: 17418408 Free article.
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C. Acton SE, et al. Among authors: rosewell i. Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814. Nature. 2014. PMID: 25341788 Free PMC article.
RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, Carvalho J, Spencer-Dene B, Herbert E, Stamp G, Damry D, Calado DP, Rosewell I, Fritsch R, Neubig RR, Molina-Arcas M, Downward J. Lionarons DA, et al. Among authors: rosewell i. Cancer Cell. 2019 Jul 8;36(1):68-83.e9. doi: 10.1016/j.ccell.2019.05.015. Epub 2019 Jun 27. Cancer Cell. 2019. PMID: 31257073 Free PMC article.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF, Cameron AJM. Murray ER, et al. Among authors: rosewell i. Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227. Cell Rep. 2022. PMID: 35081338 Free PMC article.
56 results