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Glycine: a long-sought novel ligand for GPR158.
Rosenkilde MM, Mathiesen JM. Rosenkilde MM, et al. Trends Pharmacol Sci. 2023 Aug;44(8):489-491. doi: 10.1016/j.tips.2023.05.004. Epub 2023 Jun 13. Trends Pharmacol Sci. 2023. PMID: 37321907
Ligand binding and micro-switches in 7TM receptor structures.
Nygaard R, Frimurer TM, Holst B, Rosenkilde MM, Schwartz TW. Nygaard R, et al. Among authors: rosenkilde mm. Trends Pharmacol Sci. 2009 May;30(5):249-59. doi: 10.1016/j.tips.2009.02.006. Epub 2009 Apr 16. Trends Pharmacol Sci. 2009. PMID: 19375807 Review.
Is there a 'lock' for all agonist 'keys' in 7TM receptors?
Schwartz TW, Rosenkilde MM. Schwartz TW, et al. Among authors: rosenkilde mm. Trends Pharmacol Sci. 1996 Jun;17(6):213-6. doi: 10.1016/0165-6147(96)10017-1. Trends Pharmacol Sci. 1996. PMID: 8763197 Review. No abstract available.
GPR119 as a fat sensor.
Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Hansen HS, et al. Among authors: rosenkilde mm. Trends Pharmacol Sci. 2012 Jul;33(7):374-81. doi: 10.1016/j.tips.2012.03.014. Epub 2012 May 2. Trends Pharmacol Sci. 2012. PMID: 22560300 Review.
GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment.
Gabe MBN, Skov-Jeppesen K, Gasbjerg LS, Schiellerup SP, Martinussen C, Gadgaard S, Boer GA, Oeke J, Torz LJ, Veedfald S, Svane MS, Bojsen-Møller KN, Madsbad S, Holst JJ, Hartmann B, Rosenkilde MM. Gabe MBN, et al. Among authors: rosenkilde mm. Pharmacol Res. 2022 Feb;176:106058. doi: 10.1016/j.phrs.2022.106058. Epub 2022 Jan 4. Pharmacol Res. 2022. PMID: 34995796 Clinical Trial.
Ligand entry pathways control the chemical space recognized by GPR183.
Kjær VMS, Stępniewski TM, Medel-Lacruz B, Reinmuth L, Ciba M, Rexen Ulven E, Bonomi M, Selent J, Rosenkilde MM. Kjær VMS, et al. Among authors: rosenkilde mm. Chem Sci. 2023 Sep 25;14(39):10671-10683. doi: 10.1039/d2sc05962b. eCollection 2023 Oct 11. Chem Sci. 2023. PMID: 37829039 Free PMC article.
267 results