Rosenkilde MM - Search Results

1

Ligand-selective small molecule modulators of the constitutively active vGPCR US28.

Amărandi RM, Lückmann M, Melynis M, Jakobsen MH, Fallah Z, Spiess K, Hjortø GM, Pui A, Frimurer TM, Rosenkilde MM. Amărandi RM, et al. Among authors: rosenkilde mm. Eur J Med Chem. 2018 Jul 15;155:244-254. doi: 10.1016/j.ejmech.2018.05.053. Epub 2018 May 31. Eur J Med Chem. 2018. PMID: 29886326

2

Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74.

Rosenkilde MM, Kledal TN, Bräuner-Osborne H, Schwartz TW. Rosenkilde MM, et al. J Biol Chem. 1999 Jan 8;274(2):956-61. doi: 10.1074/jbc.274.2.956. J Biol Chem. 1999. PMID: 9873037 Free article.

3

Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.

Rosenkilde MM, Kledal TN, Holst PJ, Schwartz TW. Rosenkilde MM, et al. J Biol Chem. 2000 Aug 25;275(34):26309-15. doi: 10.1074/jbc.M003800200. J Biol Chem. 2000. PMID: 10842179 Free article.

4

The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.

Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. Waldhoer M, et al. Among authors: rosenkilde mm. J Biol Chem. 2003 May 23;278(21):19473-82. doi: 10.1074/jbc.M213179200. Epub 2003 Mar 18. J Biol Chem. 2003. PMID: 12646575 Free article.

5

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction.

Heydorn A, Ward RJ, Jorgensen R, Rosenkilde MM, Frimurer TM, Milligan G, Kostenis E. Heydorn A, et al. Among authors: rosenkilde mm. Mol Pharmacol. 2004 Aug;66(2):250-9. doi: 10.1124/mol.66.2.250. Mol Pharmacol. 2004. PMID: 15266015

6

Molecular mechanism of 7TM receptor activation--a global toggle switch model.

Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE. Schwartz TW, et al. Among authors: rosenkilde mm. Annu Rev Pharmacol Toxicol. 2006;46:481-519. doi: 10.1146/annurev.pharmtox.46.120604.141218. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402913 Review.

7

GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors.

Rosenkilde MM, Schwartz TW. Rosenkilde MM, et al. Curr Top Med Chem. 2006;6(13):1319-33. doi: 10.2174/15680266106061319. Curr Top Med Chem. 2006. PMID: 16918451 Review.

8

Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI.

Rosenkilde MM, Andersen MB, Nygaard R, Frimurer TM, Schwartz TW. Rosenkilde MM, et al. Mol Pharmacol. 2007 Mar;71(3):930-41. doi: 10.1124/mol.106.030031. Epub 2006 Dec 14. Mol Pharmacol. 2007. PMID: 17170198

9

Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding.

Jensen PC, Thiele S, Ulven T, Schwartz TW, Rosenkilde MM. Jensen PC, et al. Among authors: rosenkilde mm. J Biol Chem. 2008 Aug 22;283(34):23121-8. doi: 10.1074/jbc.M803458200. Epub 2008 Jun 17. J Biol Chem. 2008. PMID: 18559339 Free article.

10

Ligand binding and micro-switches in 7TM receptor structures.

Nygaard R, Frimurer TM, Holst B, Rosenkilde MM, Schwartz TW. Nygaard R, et al. Among authors: rosenkilde mm. Trends Pharmacol Sci. 2009 May;30(5):249-59. doi: 10.1016/j.tips.2009.02.006. Epub 2009 Apr 16. Trends Pharmacol Sci. 2009. PMID: 19375807 Review.

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