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Molecular mechanism of the wake-promoting agent TAK-925.
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM. Yin J, et al. Among authors: rosenbaum dm. Nat Commun. 2022 May 25;13(1):2902. doi: 10.1038/s41467-022-30601-3. Nat Commun. 2022. PMID: 35614071 Free PMC article.
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Yin J, et al. Among authors: rosenbaum dm. Nat Struct Mol Biol. 2016 Apr;23(4):293-9. doi: 10.1038/nsmb.3183. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950369
Ligand modulation of sidechain dynamics in a wild-type human GPCR.
Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM. Clark LD, et al. Among authors: rosenbaum dm. Elife. 2017 Oct 6;6:e28505. doi: 10.7554/eLife.28505. Elife. 2017. PMID: 28984574 Free PMC article.
Crystal structure of the human NK1 tachykinin receptor.
Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM. Yin J, et al. Among authors: rosenbaum dm. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13264-13269. doi: 10.1073/pnas.1812717115. Epub 2018 Dec 11. Proc Natl Acad Sci U S A. 2018. PMID: 30538204 Free PMC article.
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. Yin J, et al. Among authors: rosenbaum dm. Nature. 2020 Aug;584(7819):125-129. doi: 10.1038/s41586-020-2379-5. Epub 2020 Jun 11. Nature. 2020. PMID: 32528175 Free PMC article.
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Hellmann J, et al. Among authors: rosenbaum dm. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18059-18067. doi: 10.1073/pnas.2002704117. Epub 2020 Jul 15. Proc Natl Acad Sci U S A. 2020. PMID: 32669442 Free PMC article.
130 results