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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Patel SJ, et al. Among authors: rosen ed. Sci Transl Med. 2022 Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320000 Free PMC article.
Charting a dynamic DNA methylation landscape of the human genome.
Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Ziller MJ, et al. Among authors: rosen ed. Nature. 2013 Aug 22;500(7463):477-81. doi: 10.1038/nature12433. Epub 2013 Aug 7. Nature. 2013. PMID: 23925113 Free PMC article.
Nuclear Mechanisms of Insulin Resistance.
Kang S, Tsai LT, Rosen ED. Kang S, et al. Among authors: rosen ed. Trends Cell Biol. 2016 May;26(5):341-351. doi: 10.1016/j.tcb.2016.01.002. Epub 2016 Jan 25. Trends Cell Biol. 2016. PMID: 26822036 Free PMC article. Review.
IRF3 promotes adipose inflammation and insulin resistance and represses browning.
Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED. Kumari M, et al. Among authors: rosen ed. J Clin Invest. 2016 Aug 1;126(8):2839-54. doi: 10.1172/JCI86080. Epub 2016 Jul 11. J Clin Invest. 2016. PMID: 27400129 Free PMC article.
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. Kazak L, et al. Among authors: rosen ed. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19. Proc Natl Acad Sci U S A. 2017. PMID: 28630339 Free PMC article.
158 results