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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. Heichler C, et al. Gut. 2020 Jul;69(7):1269-1282. doi: 10.1136/gutjnl-2019-319200. Epub 2019 Nov 4. Gut. 2020. PMID: 31685519
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schürmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Atreya R, et al. Nat Med. 2000 May;6(5):583-8. doi: 10.1038/75068. Nat Med. 2000. PMID: 10802717
IL-6 trans-signaling: the heat is on.
Rose-John S, Neurath MF. Rose-John S, et al. Immunity. 2004 Jan;20(1):2-4. doi: 10.1016/s1074-7613(04)00003-2. Immunity. 2004. PMID: 14738759 Free article.
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S. Doganci A, et al. J Clin Invest. 2005 Feb;115(2):313-25. doi: 10.1172/JCI22433. J Clin Invest. 2005. PMID: 15668741 Free PMC article.
606 results