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Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.
Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG. Ichim G, et al. Among authors: rooswinkel rw. Mol Cell. 2015 Mar 5;57(5):860-872. doi: 10.1016/j.molcel.2015.01.018. Epub 2015 Feb 19. Mol Cell. 2015. PMID: 25702873 Free PMC article.
Combining radiotherapy with APO010 in cancer treatment.
Verbrugge I, Wissink EH, Rooswinkel RW, Jongsma J, Beltraminelli N, Dupuis M, Borst J, Verheij M. Verbrugge I, et al. Among authors: rooswinkel rw. Clin Cancer Res. 2009 Mar 15;15(6):2031-8. doi: 10.1158/1078-0432.CCR-08-2125. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276268
Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, Rooswinkel RW, van Tellingen O, Rosing H, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: rooswinkel rw. Cancer Res. 2009 Dec 1;69(23):8996-9002. doi: 10.1158/0008-5472.CAN-09-2915. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920203 Free article.
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
van Waterschoot RA, ter Heine R, Wagenaar E, van der Kruijssen CM, Rooswinkel RW, Huitema AD, Beijnen JH, Schinkel AH. van Waterschoot RA, et al. Among authors: rooswinkel rw. Br J Pharmacol. 2010 Jul;160(5):1224-33. doi: 10.1111/j.1476-5381.2010.00759.x. Br J Pharmacol. 2010. PMID: 20590614 Free PMC article.
15 results