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Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP.
De Waele L, Curie A, Kangro K, Tellier E, Kaplanski G, Männik A, Tersteeg C, Joly BS, Coppo P, Veyradier A, De Meyer SF, Roose E, Vanhoorelbeke K. De Waele L, et al. Among authors: roose e. Blood Adv. 2021 Nov 9;5(21):4480-4484. doi: 10.1182/bloodadvances.2021004971. Blood Adv. 2021. PMID: 34559219 Free PMC article.
Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.
Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Deforche L, et al. Among authors: roose e. J Thromb Haemost. 2015 Nov;13(11):2063-75. doi: 10.1111/jth.13149. Epub 2015 Oct 20. J Thromb Haemost. 2015. PMID: 26391536 Free PMC article.
Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.
Deforche L, Tersteeg C, Roose E, Vandenbulcke A, Vandeputte N, Pareyn I, De Cock E, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Deforche L, et al. Among authors: roose e. PLoS One. 2016 Aug 1;11(8):e0160388. doi: 10.1371/journal.pone.0160388. eCollection 2016. PLoS One. 2016. PMID: 27479501 Free PMC article.
Role of ADAMTS13 in diet-induced liver steatosis.
Geys L, Roose E, Vanhoorelbeke K, Bedossa P, Scroyen I, Lijnen HR. Geys L, et al. Among authors: roose e. Mol Med Rep. 2017 Aug;16(2):1451-1458. doi: 10.3892/mmr.2017.6714. Epub 2017 Jun 7. Mol Med Rep. 2017. PMID: 29067443
54 results