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Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.
Toxicol Appl Pharmacol. 2017 May 15;323:74-80. doi: 10.1016/j.taap.2017.03.012. Epub 2017 Mar 20.
Toxicol Appl Pharmacol. 2017.
PMID: 28336214
Free PMC article.
Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Moyer BJ, Rojas IY, Kerley-Hamilton JS, Hazlett HF, Nemani KV, Trask HW, West RJ, Lupien LE, Collins AJ, Ringelberg CS, Gimi B, Kinlaw WB 3rd, Tomlinson CR.
Moyer BJ, et al. Among authors: rojas iy.
Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. doi: 10.1016/j.taap.2016.03.011. Epub 2016 Mar 25.
Toxicol Appl Pharmacol. 2016.
PMID: 27020609
Free PMC article.
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Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.
Moyer BJ, Rojas IY, Kerley-Hamilton JS, Nemani KV, Trask HW, Ringelberg CS, Gimi B, Demidenko E, Tomlinson CR.
Moyer BJ, et al. Among authors: rojas iy.
Nutr Res. 2017 Aug;44:38-50. doi: 10.1016/j.nutres.2017.06.002. Epub 2017 Jun 28.
Nutr Res. 2017.
PMID: 28821316
Free PMC article.
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Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin.
Rojas IY, Moyer BJ, Ringelberg CS, Tomlinson CR.
Rojas IY, et al.
Int J Obes (Lond). 2020 Apr;44(4):948-963. doi: 10.1038/s41366-019-0512-z. Epub 2020 Jan 7.
Int J Obes (Lond). 2020.
PMID: 31911663
Free PMC article.
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Kynurenine-Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia.
Rojas IY, Moyer BJ, Ringelberg CS, Wilkins OM, Pooler DB, Ness DB, Coker S, Tosteson TD, Lewis LD, Chamberlin MD, Tomlinson CR.
Rojas IY, et al.
Obesity (Silver Spring). 2021 Feb;29(2):337-349. doi: 10.1002/oby.23065.
Obesity (Silver Spring). 2021.
PMID: 33491319
Free PMC article.
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