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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA. O'Neill PM, et al. Among authors: rodrigues j. Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159. Nat Commun. 2017. PMID: 28537265 Free PMC article.
Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen.
Miguel-Blanco C, Molina I, Bardera AI, Díaz B, de Las Heras L, Lozano S, González C, Rodrigues J, Delves MJ, Ruecker A, Colmenarejo G, Viera S, Martínez-Martínez MS, Fernández E, Baum J, Sinden RE, Herreros E. Miguel-Blanco C, et al. Among authors: rodrigues j. Nat Commun. 2017 May 17;8:15160. doi: 10.1038/ncomms15160. Nat Commun. 2017. PMID: 28513586 Free PMC article.
Gametocytes from K13 Propeller Mutant Plasmodium falciparum Clinical Isolates Demonstrate Reduced Susceptibility to Dihydroartemisinin in the Male Gamete Exflagellation Inhibition Assay.
Lozano S, Gamallo P, González-Cortés C, Presa Matilla JL, Fairhurst RM, Herreros E, Amaratunga C, Rodrigues J. Lozano S, et al. Among authors: rodrigues j. Antimicrob Agents Chemother. 2018 Nov 26;62(12):e01426-18. doi: 10.1128/AAC.01426-18. Print 2018 Dec. Antimicrob Agents Chemother. 2018. PMID: 30224530 Free PMC article.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RDJ, Le Manach C, Paquet T, González Cabrera D, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz LM. van der Watt ME, et al. Among authors: rodrigues jfi. J Antimicrob Chemother. 2018 May 1;73(5):1279-1290. doi: 10.1093/jac/dky008. J Antimicrob Chemother. 2018. PMID: 29420756
Fighting Shigella by Blocking Its Disease-Causing Toxin.
Haksar D, Asadpoor M, Heise T, Shi J, Braber S, Folkerts G, Ballell L, Rodrigues J, Pieters RJ. Haksar D, et al. Among authors: rodrigues j. J Med Chem. 2021 May 13;64(9):6059-6069. doi: 10.1021/acs.jmedchem.1c00152. Epub 2021 Apr 28. J Med Chem. 2021. PMID: 33909975 Free PMC article.
Smoking, mortality, access to diagnosis, and treatment of lung cancer in Brazil.
Campos MR, Rodrigues JM, Marques AP, Faria LV, Valerio TS, Silva MJSD, Pires DC, Chaves LA, Cardoso CHD, Campos SR, Emmerick ICM. Campos MR, et al. Among authors: rodrigues jm. Rev Saude Publica. 2024 May 13;58:18. doi: 10.11606/s1518-8787.2024058005704. eCollection 2024. Rev Saude Publica. 2024. PMID: 38747866 English, Portuguese.
Ontogenetic and sexual differences in the venom of Bothrops moojeni: insights from a litter and its mother.
Ferreira-Rodrigues SC, Silva RCC, Trevisan M, Rodrigues PSM, Del-Rei THM, Sousa LF, Vilarinho ARG, Lima CA, Rodrigues JL, Silva MMR, Moura-da-Silva AM, Sant'Anna SS, Seibert CS. Ferreira-Rodrigues SC, et al. Among authors: rodrigues jl. Braz J Biol. 2024 May 13;84:e279474. doi: 10.1590/1519-6984.279474. eCollection 2024. Braz J Biol. 2024. PMID: 38747862
Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents.
Cezar RD, Silva AOD, Lopes RS, Nakamura CV, Rodrigues JHS, Lourenço EMG, Saba S, Beatriz A, Rafique J, Lima DP. Cezar RD, et al. Among authors: rodrigues jhs. An Acad Bras Cienc. 2024 May 13;96(2):e20230375. doi: 10.1590/0001-3765202420230375. eCollection 2024. An Acad Bras Cienc. 2024. PMID: 38747836
3,324 results